|
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Corticotropin releasing factor (CRF) signaling and CRF neurons in the bed nucleus of the stria terminalis (BNST) drive negative affective behaviors, thus agents that decrease activity of these cells may be of therapeutic interest.
|
30478032 |
2019 |
|
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Next, the role of corticotropin-releasing factor (CRF) signaling within the dlBNST in the increased sIPSCs was examined.
|
31451580 |
2019 |
|
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing factor (CRF) regulates stress responses, and aberrant CRF signals are associated with depressive disorders.
|
31017816 |
2019 |
|
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Corticotropin releasing factor (CRF) signaling via limbic CRF1 and 2 receptors (CRF1R and CRF2R, respectively) is known to modulate binge-like ethanol consumption in rodents.
|
31330967 |
2019 |
|
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Numerous studies suggest that stress-induced reinstatement to drug-seeking behaviors is mediated by norepinephrine (NE) and corticotropin-releasing factor (CRF) signaling interactions in the bed nucleus of the stria terminalis (BNST), a brain region critical to many behavioral and physiologic responses to stressors.
|
31141179 |
2019 |
|
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Decades of research have described the importance of corticotropin-releasing factor (CRF) signaling in alcohol addiction, as well as in commonly co-expressed neuropsychiatric diseases, including anxiety and mood disorders.
|
30217435 |
2018 |
|
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Convergent anatomical, molecular, pharmacological and functional experimental evidence supports a key role of brain CRF receptor (CRF-R) signaling in stress-related alterations of gastrointestinal functions.
|
28240194 |
2018 |
|
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine whether the effect of stress is mimicked by the activation of corticotropin-releasing factor (CRF) signaling in the brain, rats with latent sensitization induced by injecting complete Freund's adjuvant (CFA, 50 μl) in one hind paw were given an intracerebroventricular (i.c.v.) injection of CRF.The i.c.v. injection of CRF (0.6 μg, 10 μl), but not saline, induced bilateral mechanical hyperalgesia in rats with latent sensitization.In contrast, CRF i.c.v. did not induce hyperalgesia in rats without latent sensitization (injected with saline in the hind paw).
|
29776484 |
2018 |
|
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the drug discovery of CRF<sub>1</sub> receptor antagonists, we identified two types of compounds, Compound A and Compound B, which antagonized peripheral CRF-induced HPA axis activation to the same extent, but showed different effects on the central CRF signal.
|
28689880 |
2017 |
|
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we investigated the influence of chronic social stress (CSS) in pigs, induced by 7 d of chronic mixing/crowding stress, on intestinal barrier and nutrient transport function, corticotropin releasing factor (CRF) signaling and immunological responses.
|
28170426 |
2017 |
|
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing factor (CRF) signaling at the CRF<sub>1</sub> receptor (CRF<sub>1</sub>R) in the ventral tegmental area (VTA) can modulate ethanol consumption in rodents.
|
27113502 |
2017 |
|
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing factor (CRF) signaling through CRF receptor 1 (CRFR1) regulates autonomic, endocrine and behavioral responses to stress and has been implicated in the pathophysiology of several disorders including anxiety, depression, and addiction.
|
28823817 |
2017 |
|
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing factor (CRF) signaling in the central nucleus of the amygdala (CeA) is hypothesized to drive the development of alcohol dependence, as it regulates ethanol intake and several anxiogenic behaviors linked to withdrawal.
|
28807676 |
2017 |
|
Kidney Failure, Chronic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The effect of native LDL (nLDL) from patients with chronic renal failure (CRF-nLDL) on glucose uptake was also determined.
|
25779204 |
2015 |
|
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, intrathecal injection of CRF receptor antagonist (α-helical-CRF) significantly inhibited heat hyperalgesia, mechanical allodynia, and the expression of c-Fos in spinal dorsal horn of bone cancer pain rats.
|
26138585 |
2015 |
|
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Next generation sequencing of the patients who progressed to ESKD failed to reveal a second mutation in any of the COL4A3/A4/A5 genes, supporting that true heterozygosity for COL4A3/A4 mutations predisposes to CRF/ESKD.
|
25514610 |
2014 |
|
Kidney Failure, Chronic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Biochemical coding of stress involves the recruitment of corticotropin releasing factor (CRF) signaling pathways.
|
21575632 |
2012 |