CRH, corticotropin releasing hormone, 1392

N. diseases: 402; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological
0.100 Biomarker disease BEFREE We have previously demonstrated that activation of the corticotropin-releasing factor (CRF) system potentiates MC degranulation responses during IgE-mediated anaphylaxis and psychological stress through corticotropin-releasing factor receptor subtype 1 (CRF<sub>1</sub>) expressed on MCs. 30439403 2019
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological
0.100 Biomarker disease BEFREE We investigated the contribution of psychological stress (PS) and CRF on bladder function. 31285518 2019
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological
0.100 Biomarker disease BEFREE This study shows no evidence for a dysregulation of the HPA axis as measured by the DEX/CRH test in depressed women with and without childhood adversity as compared to mentally healthy women with or without early life stress. 29080551 2018
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological
0.100 Biomarker disease BEFREE Maternal deprivation is a severe early-life stress that alters CRF neural circuitry and is likewise associated with abnormal mental health later in life. 29511121 2018
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological
0.100 Biomarker disease BEFREE TLR4 has a limited role in CRF's activation of the CeA under basal conditions, but interacts with the CRF system to regulate GABAergic synapse function in animals that experience repeated psychological stress. 29309503 2018
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological
0.100 GeneticVariation disease BEFREE To investigate the combined contribution of hypothalamic-pituitary-adrenal (HPA) reactivity and environmental stressors (e.g., ongoing life stress) to relapse severity in alcohol-dependent men following treatment, plasma adrenocorticotropin (ACTH) and cortisol were obtained in 4-6 weeks abstinent alcohol-dependent men (n=41) following a psychosocial stressor [the Trier Social Stress Test (TSST)] and two pharmacological provocations [ovine corticotropin releasing factor (oCRH) and cosyntropin]. 27888772 2017
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological
0.100 Biomarker disease BEFREE The interaction of corticotropin-releasing hormone receptor gene and early life stress on emotional empathy. 28461011 2017
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological
0.100 Biomarker disease BEFREE In this article, we reviewed the role of CRF, pro-opiomelanocortin (POMC)-derived peptides, GCs of the HPA, and 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in AD, with a discussion of the pathogenetic mechanisms of inflammation and skin barrier functions, including antimicrobial defense, and their association with PS. 29023418 2017
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological
0.100 Biomarker disease BEFREE We conclude that CRH and CRHR-1 are altered by psychological stress and play an important role in the pathogenesis of vitiligo. 27663146 2016
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological
0.100 Biomarker disease BEFREE Interaction of early life stress and corticotropin-releasing hormone receptor gene: effects on working memory. 24931706 2014
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological
0.100 Biomarker disease BEFREE Psychological stress-derived CRF can breach the established endotoxin tolerance in the intestinal mucosa. 23840363 2013
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological
0.100 GeneticVariation disease BEFREE Variation in the corticotropin-releasing hormone receptor (CRHR1) gene has been shown to interact with early life stress to predict adult depression. 19596121 2009
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological
0.100 Biomarker disease BEFREE Interleukin-1 (IL-1) mediates psychological stress responses by regulating monoamine metabolism and secretion of corticotropin-releasing factor, and is therefore, implicated in various psychiatric diseases. 12804791 2003