|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The central thesis is that stress leads to changes in corticotropin-releasing factor in the brain that impact addiction.
|
30227143 |
2019 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats.
|
30886240 |
2019 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The corticotropin-releasing factor (CRF) system is a key mediator of the stress response and addictive behavior.
|
29515519 |
2018 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These findings highlight CRF receptors as potential therapeutic targets to be explored by research about stress-related addiction problems.
|
29391155 |
2018 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The class B corticotropin-releasing hormone type 1 receptor (CRHR1) is a key player in the stress response whose dysregulation is critically involved in stress-related disorders: psychiatric conditions (i.e. depression, anxiety, and addictions), neuroendocrinological alterations, and neurodegenerative diseases.
|
30427333 |
2018 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This study assesses the regional expression of the transcripts of the CRF transmission in a nicotine sensitization model, since it is hypothesised that the molecular neuroadaptations that mediate the development of sensitization contribute to the development of addiction.
|
29857328 |
2018 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Specific contributions about this interaction include the study of CRF receptors in the lateral septum, investigations on the neural mechanisms of cross-sensitization for psychostimulants and ethanol, the identification of the Wnt/β-catenin pathway as a critical neural substrate for stress and addiction, and the emergence of the cannabinoid system as a promising therapeutic target.
|
30622500 |
2018 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Yet, much remains to be learned about CRF's role in the neurobiology of dysphoria and addiction and the potential for novel anti-CRF therapies therein.
|
28265716 |
2017 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Corticotropin-releasing factor (CRF) signaling through CRF receptor 1 (CRFR1) regulates autonomic, endocrine and behavioral responses to stress and has been implicated in the pathophysiology of several disorders including anxiety, depression, and addiction.
|
28823817 |
2017 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Over this time, CRF arguably gained more attention as a target for development of addiction pharmacotherapies.
|
29056150 |
2017 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In this chapter we focus on behavioral and cellular neuropharmacological studies that have implicated brain stress systems (i.e., corticotropin-releasing factor [CRF]) in the transition to addiction and the predominant brain regions involved.
|
29056155 |
2017 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
CRH is an important integrator of neuroendocrine stress responses in the brain, with a key role in the addiction processes.
|
28319850 |
2017 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The results of many studies support the influence of the corticotropin-releasing factor (CRF) system on ethanol (EtOH) consumption and EtOH-induced neuroadaptations that are critical in the addiction process.
|
25565358 |
2015 |
|
Addictive Behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In the present review, derived from the 2012 Behavior, Biology and Chemistry "Translational Research in Addiction" symposium, we summarize the anti-relapse potential of corticotropin-releasing factor type 1 (CRF(1)) receptor antagonists to reduce negative emotional symptoms of acute and protracted alcohol withdrawal and stress-induced relapse to alcohol seeking.
|
23294766 |
2013 |