CRH, corticotropin releasing hormone, 1392

N. diseases: 274; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 AlteredExpression group BEFREE The involvement of retinoic acid receptor-alpha in corticotropin-releasing hormone gene expression and affective disorders. 19596122 2010
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group PSYGENET These results suggest that RAR-alpha might contribute to regulating the activity of CRH neurons in vivo, and the vulnerable character of the critical proteins in RA signaling pathways might provide novel targets for therapeutic strategies for depression. 19596122 2010
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group PSYGENET Hypersecretion of central corticotropin-releasing hormone (CRH) has been implicated in the pathophysiology of affective disorders. 18475271 2009
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group PSYGENET The subsequent gender analysis showed significant associations of three SNPs (CRF-BPs2 T; CRF-BPs11 T and CRF-BPs12 C) and haplotype G_T_C_T_C with MDD in Swedish males. 17599466 2008
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group PSYGENET Corticotropin-releasing factor (CRF), its receptors, and signaling pathways that regulate CRF expression and responses are areas of intense investigation for new drugs to treat affective disorders. 17908177 2008
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Corticotropin-releasing factor-binding protein (CRF-BP) regulates the availability of free CRF and is a functional candidate gene for affective disorders. 17599466 2008
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Corticotropin-releasing factor-binding protein regulates the availability of free corticotropin-releasing factor and is a functional candidate gene for affective disorders. 17728670 2007
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group PSYGENET Corticotropin-releasing factor-binding protein regulates the availability of free corticotropin-releasing factor and is a functional candidate gene for affective disorders. 17728670 2007
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE We conclude that androgens may directly affect CRH neurons in the human PVN via AR binding to the CRH-ARE, which may have consequences for sex-specific pathogenesis of mood disorders. 16446741 2006
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Dysfunctioning of corticotropin-releasing factor (CRF) and its receptors (CRF(1) and CRF(2)) has been linked to the development of stress-related disorders, such as affective disorders and drug abuse. 16611089 2006
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Getting closer to affective disorders: the role of CRH receptor systems. 15310462 2005
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Listening to mutant mice: a spotlight on the role of CRF/CRF receptor systems in affective disorders. 15899517 2005
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Given the fundamental role of the corticotropin-releasing hormone (CRH) system in anxiety, stress-associated pathologies, and mood disorders, we describe genetic modifications of the genes that encode proteins integral to the CRH/CRH receptor system with particular emphasis on conditional gene-targeting strategies. 14755129 2004
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders. 11337098 2001
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE CRF overproduction has been implicated in affective disorders, such as depression and anorexia nervosa, and may lead to Cushing's syndrome. 1597149 1992