Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
This similarity lends support to the concept of a common tumorigenic pathway between WT with aberrant WTX and those without.
|
28326956 |
2019 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in WTX are found in Wilms tumor, a form of pediatric kidney cancer and in patients suffering from OSCS (Osteopathia striata with cranial sclerosis), a sclerosing bone disorder.
|
31290212 |
2019 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
WTX encodes a tumor suppressor implicated in the pediatric kidney cancer Wilms tumor and in mesenchymal differentiation with potentially distinct functions in the cytoplasm, at the plasma membrane, and in the nucleus.
|
25882849 |
2015 |
Childhood Kidney Wilms Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
WTX is a tumor suppressor gene expressed during embryonic development and inactivated in 20-30% of cases of Wilms tumor, the most common pediatric kidney cancer.
|
24249259 |
2014 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This has been illustrated by the findings that mutations of Wnt/β-catenin pathway-related WT1, β-catenin, and WTX together account for about one-third of Wilms tumor cases.
|
25018051 |
2014 |
Childhood Kidney Wilms Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Stat3 inhibits WTX expression through up-regulation of microRNA-370 in Wilms tumor.
|
23333300 |
2013 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Other genes frequently altered somatically in subsets of WT are CTNNB1 and WTX; both genes influence the Wnt signalling pathway.
|
22461142 |
2013 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The 17.94 cell line contained a TP53 mutation, consistent with the anaplastic histology of the original tumor, but lacked mutations in WT1, WTX, or CTNNB1, which are the other genes involved in WT pathogenesis.
|
22749038 |
2012 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The role of WTX/WT1 in the development of Wilms' tumor, and the relationship between clinical phenotype and genotype, were also studied.
|
22800892 |
2012 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found that abnormalities of WTX and CTNNB1 were mutually exclusive, and that although CTNNB1 mutation was frequent in WTs with WT1 abnormality, but rare in WTs without, the incidences of WTX abnormality were similar between WTs with or without WT1 abnormality.
|
22409817 |
2012 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Functional characterization of Wilms tumor-suppressor WTX and tumor-associated mutants.
|
20956941 |
2011 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Wilms' tumor (WT), the most common pediatric renal malignancy, is associated with mutations in several well-characterized genes, most notably WT1, CTNNB1, WTX, and TP53.
|
20332316 |
2010 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Inactivation of Wilms tumor X (WTX) gene has been linked to the pathogenesis of a varying percentage of nephroblastomas.
|
19757195 |
2010 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Germline WTX mutations cause an X-linked sclerosing bone dysplasia but do not appear to predispose to Wilms tumor formation.
|
20168230 |
2010 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently in Wilms tumors, WTX (Wilms tumor gene on the X-chromosome) was discovered as another gene involved in the destruction of beta-CATENIN.
|
20696052 |
2010 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
WTX has also been shown to be somatically inactivated in 11-29% of cases of Wilms tumor.
|
19079258 |
2009 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Wilms tumor is also genetically heterogeneous and is associated with mutations of WT1 (15-20%), WTX (20-30%) and other loci.
|
19294427 |
2009 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The WTX gene is now the most common known gene mutation in Wilms' tumor.
|
18391632 |
2008 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.
|
17510365 |
2007 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The recent description of a new X chromosome tumor suppressor gene, WTX, that is commonly inactivated in Wilms' tumor prompted us to examine the possible involvement of WTX in a case of Wilms' tumor containing an apparently balanced reciprocal translocation between chromosomes X and 18 (t(X;18)(q11;p11)).
|
17620295 |
2007 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
An X chromosome gene, WTX, is commonly inactivated in Wilms tumor.
|
17204608 |
2007 |