|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
When all subjects were grouped based on family history of mental illness, there was a statistically significant association of CRHR1 rs242941 with family history regardless of depression status (P = 0.043).
|
26518448 |
2015 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
This study was conducted to determine whether CRHR1 polymorphisms interact with childhood maltreatment to predict hypothalamic-pituitary-adrenal (HPA) axis reactivity, which has been linked to both depression and early life stress.
|
19596121 |
2009 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The complex structure of CRHR1 may help to explain why some variants in the gene moderate the effects of an ACE only on depression risk while others moderate the effect of an ACE only on AD risk.
|
21998007 |
2011 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS to predict depression, cognitive functions and hippocampal activity.
|
28461011 |
2017 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These data demonstrate that the CRHR1 TAT haplotype is associated with cognitive features of depression including difficulty with decision-making, higher rumination, and poorer learning and memory.
|
29317606 |
2018 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The present study partially replicates recent findings of a CRHR1 by childhood adversity interaction with regard to adult depression highlighting the subjective characteristics of the environmental pathogen that is operative in this interaction.
|
22748421 |
2013 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Although we did not replicate the specific interaction of abuse and the TAT-haplotype of the CRHR1 gene we confirmed the relevance of an interplay between variants within the CRHR1 gene and childhood adversities in the modulation of depression in adults.
|
20957648 |
2010 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
To replicate the interaction between childhood maltreatment and a TAT haplotype formed by rs7209436, rs110402, and rs242924 in CRHR1, predicting adult depression.
|
19736354 |
2009 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children.
|
25422957 |
2014 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Variants in the corticotropin-releasing hormone receptor 1 (CRHR1) gene have been associated with alcoholism and depression.
|
25802844 |
2015 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Previous research supports gene-environment interactions for polymorphisms in the corticotropin hormone receptor 1 gene (CRHR1) and the serotonin transporter gene linked polymorphic region (5-HTTLPR) in predicting depression, but it has rarely considered genetic influences on stress sensitization processes, whereby early adversities (EA) increase depressive reactivity to proximal stressors later in life.
|
25422958 |
2014 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Increasing evidence have indicated the strong association of stress, especially the chronic stress and early life stress, with depressive disorders development, while the association of stress with depression is moderated by genetic risk factors, including polymorphism of SERT, BDNF, GR, FKBP5, MR, and CRHR1.
|
31784962 |
2019 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Several studies have demonstrated that variants of the CRH-R1 gene carry a potential risk for depression, but evidence for an association between CRH-R1 genotypes and IBS is lacking.
|
22957021 |
2012 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Dysregulation in the stress response of the hypothalamic-pituitary-adrenocortical (HPA) axis, involving the corticotrophin-releasing hormone (CRH) and its main receptor (CRHR1), is associated with depression, frequent among suicidal males.
|
17376150 |
2008 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS experience to predict depression as well as neuroendocrine and neuronal reactivity.
|
24931706 |
2014 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Allelic variants of the glucocorticoid receptor (GR) gene contribute significantly to both cortisol levels and to measures of psychosis; corticotropin-releasing hormone receptor 1 variants contribute to measures of depression and psychosis.
|
24933348 |
2015 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
To comprehensively map the genetic variation in CRHR1 in relation to suicidality and depression, as a follow-up to our initial report on SNP rs4792887, we analyzed six new single nucleotide polymorphisms (SNPs), in an extended sample of family trios (n = 672) with suicide attempter offspring, by using family-based association tests.
|
19220485 |
2009 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Depression and anxiety symptoms among women who carry the FMR1 premutation: impact of raising a child with fragile X syndrome is moderated by CRHR1 polymorphisms.
|
22573456 |
2012 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Corticotropin-releasing factor binds with high affinity to CRF receptor 1 (CRFR1) and is implicated in stress-related mood disorders such as anxiety and depression.
|
30499109 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Corticotropin-releasing factor receptor type 1 (CRF1R) is a class B receptor mediating stress response and also considered a drug target for depression and anxiety.
|
28183242 |
2017 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Similarly, we recently discovered that genetic variation in components of the stress-related hypothalamic pituitary adrenocortical axis, T-box 19 and corticotropin releasing hormone receptor 1, showed association and linkage to high anger/hostility in and male depression the suicidal offspring, respectively.
|
17585962 |
2007 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Because CRHR1 affects both depression and anxiety.
|
15365580 |
2004 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Stress and anxiety disorders are risk factors for depression and these behaviors are modulated by corticotrophin-releasing factor receptor 1 (CRFR1) and serotonin receptor (5-HT(2)R).
|
20383137 |
2010 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The analysed candidate haplotypes in FKBP5, NR3C1, and CRHR1 did not show an association with depression scores as assessed by EPDS in this cohort of healthy unselected pregnant women.
|
24741566 |
2014 |