Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Corticotropin-releasing factor binds with high affinity to CRF receptor 1 (CRFR1) and is implicated in stress-related mood disorders such as anxiety and depression.
|
30499109 |
2019 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Increasing evidence have indicated the strong association of stress, especially the chronic stress and early life stress, with depressive disorders development, while the association of stress with depression is moderated by genetic risk factors, including polymorphism of SERT, BDNF, GR, FKBP5, MR, and CRHR1.
|
31784962 |
2019 |
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
EA treatment can decrease the expression of hypothalamic CRF and CRF-R1, relieve anxiety and depression, meanwhile reduce the expression of CRF-R1 in the gastrointestinal mucosa, increase ZO-1 expression, and adjust tight junctions (TJs) to repair the intestinal mucosal barrier.
|
31737064 |
2019 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These data demonstrate that the CRHR1 TAT haplotype is associated with cognitive features of depression including difficulty with decision-making, higher rumination, and poorer learning and memory.
|
29317606 |
2018 |
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In the present study, we demonstrated that chronic FS stress (CFSS) could activate corticotropin-releasing factor (CRF)/CRF receptor type 1 (CRFR1) signaling in the BLA, and blockade of CRF/CRFR1 signaling by intra-BLA injection of NBI27914 (NBI), a selective CRFR1 antagonist, could prevent the CFSS-induced depressive-like behaviors in rats, indicating that activation of CRF/CRFR1 signaling in the BLA is required for CFSS-induced depression.
|
29080675 |
2018 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Corticotropin-releasing factor receptor type 1 (CRF1R) is a class B receptor mediating stress response and also considered a drug target for depression and anxiety.
|
28183242 |
2017 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS to predict depression, cognitive functions and hippocampal activity.
|
28461011 |
2017 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
When all subjects were grouped based on family history of mental illness, there was a statistically significant association of CRHR1 rs242941 with family history regardless of depression status (P = 0.043).
|
26518448 |
2015 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Variants in the corticotropin-releasing hormone receptor 1 (CRHR1) gene have been associated with alcoholism and depression.
|
25802844 |
2015 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Allelic variants of the glucocorticoid receptor (GR) gene contribute significantly to both cortisol levels and to measures of psychosis; corticotropin-releasing hormone receptor 1 variants contribute to measures of depression and psychosis.
|
24933348 |
2015 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Growth curve models were executed to determine whether CRHR1 moderated the link between Wave 1 family economic hardship and youths' development of depression.
|
26206446 |
2015 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The analysed candidate haplotypes in FKBP5, NR3C1, and CRHR1 did not show an association with depression scores as assessed by EPDS in this cohort of healthy unselected pregnant women.
|
24741566 |
2014 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children.
|
25422957 |
2014 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Previous research supports gene-environment interactions for polymorphisms in the corticotropin hormone receptor 1 gene (CRHR1) and the serotonin transporter gene linked polymorphic region (5-HTTLPR) in predicting depression, but it has rarely considered genetic influences on stress sensitization processes, whereby early adversities (EA) increase depressive reactivity to proximal stressors later in life.
|
25422958 |
2014 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In addition, GR and corticotropin-releasing hormone receptor 1 (CRHR1) genotypes contributed significantly to psychosis measures and CRHR1 contributed significantly to depression severity rating.
|
24166410 |
2014 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS experience to predict depression as well as neuroendocrine and neuronal reactivity.
|
24931706 |
2014 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The present study partially replicates recent findings of a CRHR1 by childhood adversity interaction with regard to adult depression highlighting the subjective characteristics of the environmental pathogen that is operative in this interaction.
|
22748421 |
2013 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Several studies have demonstrated that variants of the CRH-R1 gene carry a potential risk for depression, but evidence for an association between CRH-R1 genotypes and IBS is lacking.
|
22957021 |
2012 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Depression and anxiety symptoms among women who carry the FMR1 premutation: impact of raising a child with fragile X syndrome is moderated by CRHR1 polymorphisms.
|
22573456 |
2012 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The complex structure of CRHR1 may help to explain why some variants in the gene moderate the effects of an ACE only on depression risk while others moderate the effect of an ACE only on AD risk.
|
21998007 |
2011 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Stress and anxiety disorders are risk factors for depression and these behaviors are modulated by corticotrophin-releasing factor receptor 1 (CRFR1) and serotonin receptor (5-HT(2)R).
|
20383137 |
2010 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Although we did not replicate the specific interaction of abuse and the TAT-haplotype of the CRHR1 gene we confirmed the relevance of an interplay between variants within the CRHR1 gene and childhood adversities in the modulation of depression in adults.
|
20957648 |
2010 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We also found suggestive associations in women for GAD1, GRIA3, and BDNF with depression accompanied by fatigue, and for CRHR1 with depression accompanied by early morning awakenings.
|
19548263 |
2010 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
This study was conducted to determine whether CRHR1 polymorphisms interact with childhood maltreatment to predict hypothalamic-pituitary-adrenal (HPA) axis reactivity, which has been linked to both depression and early life stress.
|
19596121 |
2009 |