|
Abnormal behavior
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Thus, this study showed that alterations in CRHR1 gene were associated with higher levels of IL-1β, and increased risk for suicide, reinforcing the importance of multifactorial interactions of biological markers for psychiatric disorders.
|
27894002 |
2017 |
|
Abnormal behavior
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
More specifically, variants in the gene encoding the CRF(1) receptor interact with adverse environmental factors to predict risk for stress-related psychiatric disorders.
|
20010888 |
2010 |
|
Abnormal behavior
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Thus, our findings show that the interaction between β-arrestins and PDZ proteins is key for CRFR1 trafficking and may be targeted to mitigate impaired CRFR1 signaling in mental and psychiatric disorders.
|
31344440 |
2019 |
|
ACTH-Secreting Pituitary Adenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We suggest that the overexpression of the CRF1-R messenger RNA may be related to a disturbed receptor regulation in ACTH-secreting pituitary adenomas.
|
9745449 |
1998 |
|
Acute lymphocytic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Because CRHR1 polymorphisms have been associated with other corticosteroid effects, our goal was to define whether CRHR1 polymorphisms predict which patients with ALL are likely to develop bone mineral deficits.
|
18565889 |
2008 |
|
Addictive Behavior
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Corticotropin-releasing factor (CRF) signaling through CRF receptor 1 (CRFR1) regulates autonomic, endocrine and behavioral responses to stress and has been implicated in the pathophysiology of several disorders including anxiety, depression, and addiction.
|
28823817 |
2017 |
|
Addictive Behavior
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
In the present review, derived from the 2012 Behavior, Biology and Chemistry "Translational Research in Addiction" symposium, we summarize the anti-relapse potential of corticotropin-releasing factor type 1 (CRF(1)) receptor antagonists to reduce negative emotional symptoms of acute and protracted alcohol withdrawal and stress-induced relapse to alcohol seeking.
|
23294766 |
2013 |
|
Addictive Behavior
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
The class B corticotropin-releasing hormone type 1 receptor (CRHR1) is a key player in the stress response whose dysregulation is critically involved in stress-related disorders: psychiatric conditions (i.e. depression, anxiety, and addictions), neuroendocrinological alterations, and neurodegenerative diseases.
|
30427333 |
2018 |
|
Addictive Behavior
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Genetic association of human Corticotropin-Releasing Hormone Receptor 1 (CRHR1) with Internet gaming addiction in Korean male adolescents.
|
30572854 |
2018 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
LHGDN |
CRH inhibits cell growth of human endometrial adenocarcinoma cells via CRH-receptor 1-mediated activation of cAMP-PKA pathway.
|
11861501 |
2002 |
|
Adenoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Whereas ACTH-producing adenomas preferentially express CRF(1) receptors, nonfunctioning adenomas (gonadotropin-producing and null-cell adenomas) and GH- and TSH-producing adenomas express CRF(2) receptors.
|
12843181 |
2003 |
|
Adenoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
However, we found a significant overexpression of the CRF1-R messenger RNA in ACTH-secreting pituitary adenomas vs. inactive adenomas and normal pituitaries.
|
9745449 |
1998 |
|
Adrenal Gland Hyperfunction
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The present study aimed to investigate mutations in the CRHR1 coding region in poodles with pituitary-dependent hyperadrenocorticism.
|
29069262 |
2017 |
|
Adult Acute Lymphocytic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Because CRHR1 polymorphisms have been associated with other corticosteroid effects, our goal was to define whether CRHR1 polymorphisms predict which patients with ALL are likely to develop bone mineral deficits.
|
18565889 |
2008 |
|
Alcohol abuse
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This work provides support for a model in which CRHR1 gene variation modulates the risk of problem drinking via an internalizing/negative affect pathway involving rVLPFC and reappraisal of negative emotion.
|
24623788 |
2014 |
|
Alcohol Use Disorder
|
0.050 |
Biomarker
|
disease |
BEFREE |
A prototypical example is that of corticotropin releasing factor type 1 receptor (CRF1R) antagonists that showed significant effectiveness in animal models of AUD but were largely ineffective in humans.
|
31112713 |
2019 |
|
Alcohol Use Disorder
|
0.050 |
Biomarker
|
disease |
BEFREE |
Association of CRHR1 and CRHBP genotypes with the following: (1) AUD; (2) a newly developed alcoholism severity score comprising 5 AUD-relevant variables; and (3) quantitative CRHR1 and CRHBP messenger RNA expression.
|
21810631 |
2011 |
|
Alcohol Use Disorder
|
0.050 |
Biomarker
|
disease |
BEFREE |
Our findings support results from animal models, suggesting an importance of CRHR1 in integrating gene-environment effects in alcohol use disorders.
|
16550213 |
2006 |
|
Alcohol Use Disorder
|
0.050 |
Biomarker
|
disease |
BEFREE |
The Corticotropin Releasing Factor Receptor 1 in Alcohol Use Disorder: Still a Valid Drug Target?
|
28940382 |
2017 |
|
Alcohol Use Disorder
|
0.050 |
Biomarker
|
disease |
BEFREE |
Mice with a history of episodic social defeat stress were selectively sensitive to the effects of CRF-R1 antagonism, suggesting that CRF-R1 may be a potential target for treating alcohol use disorders in individuals who escalate their drinking after exposure to repeated bouts of psychosocial stress.
|
29696309 |
2018 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
PSYGENET |
This study extends the literature on the interplay between CRHR1 variation and alcoholism, in the context of exposure to traumatic stress.
|
23473364 |
2013 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The complex structure of CRHR1 may help to explain why some variants in the gene moderate the effects of an ACE only on depression risk while others moderate the effect of an ACE only on AD risk.
|
21998007 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Association of CRHR1 and CRHBP genotypes with the following: (1) AUD; (2) a newly developed alcoholism severity score comprising 5 AUD-relevant variables; and (3) quantitative CRHR1 and CRHBP messenger RNA expression.
|
21810631 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Ongoing clinical trials with pexacerfont and verucerfont in moderately to highly severe dependent anxious alcoholics may yield insight as to the role of CRF(1) receptor antagonists in a personalized medicine approach to treat drug or alcohol dependence.
|
23294766 |
2013 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The goals of this commentary are to discuss the important contributions of the work by Kaur and colleagues titled "Corticotropin-releasing factor acting on corticotropin-releasing factor receptor type 1 is critical for binge alcohol drinking in mice," published in this issue of Alcoholism: Clinical and Experimental Research, and to highlight the importance of preclinical research aimed at identifying the neurobiology of binge ethanol drinking.
|
22283808 |
2012 |