|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Depression and anxiety symptoms among women who carry the FMR1 premutation: impact of raising a child with fragile X syndrome is moderated by CRHR1 polymorphisms.
|
22573456 |
2012 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Depression and anxiety symptoms among women who carry the FMR1 premutation: impact of raising a child with fragile X syndrome is moderated by CRHR1 polymorphisms.
|
22573456 |
2012 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Depression and anxiety symptoms among women who carry the FMR1 premutation: impact of raising a child with fragile X syndrome is moderated by CRHR1 polymorphisms.
|
22573456 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Alcohol dependence is associated with increased corticotropin releasing factor (CRF) influence on CeA GABA release and CRF type 1 receptor (CRF(1)) antagonists prevent the excessive alcohol consumption associated with dependence.
|
23220399 |
2013 |
|
Chronic urticaria
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Corticotropin-releasing hormone receptor-1 and histidine decarboxylase expression in chronic urticaria.
|
16297195 |
2005 |
|
Mood Disorders
|
0.360 |
Biomarker
|
group |
BEFREE |
Corticotropin-releasing factor receptor antagonists in affective disorders and drug dependence-- an update.
|
16611089 |
2006 |
|
Mood Disorders
|
0.360 |
Biomarker
|
group |
PSYGENET |
Corticotropin-releasing factor receptor antagonists in affective disorders and drug dependence-- an update.
|
16611089 |
2006 |
|
Drug Dependence
|
0.010 |
Biomarker
|
group |
BEFREE |
Corticotropin-releasing factor receptor antagonists in affective disorders and drug dependence-- an update.
|
16611089 |
2006 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
CRF-R1 activation inhibits cell growth and proliferation of a tumor cell line derived from the human endometrium, and the UCN signaling pathway has been implicated in tumorigenesis of several tissues.
|
16837614 |
2006 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
CRF-R1 activation inhibits cell growth and proliferation of a tumor cell line derived from the human endometrium, and the UCN signaling pathway has been implicated in tumorigenesis of several tissues.
|
16837614 |
2006 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
CRHR1 polymorphisms predict bone density in survivors of acute lymphoblastic leukemia.
|
18565889 |
2008 |
|
Asthma
|
0.040 |
Biomarker
|
disease |
BEFREE |
CRHR1 is located within the inversion region and associated with inhaled corticosteroid response in asthma.
|
18622266 |
2008 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
CRHR1 was genotyped in 83 controls and a preliminary sample of 16 unmedicated patients with MDD who completed a functional magnetic resonance imaging scan while viewing blocks of positive, negative, and neutral words.
|
22378896 |
2012 |
|
Ulcerative Colitis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Corticotropin-releasing factor receptor subtype 2 in human colonic mucosa: down-regulation in ulcerative colitis.
|
23539366 |
2013 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Crhr1-deficient (Crhr1(-/-)) mice were used to explore the role of CRHR1 in the development of azoxymethane (AOM) and dextran sodium sulfate (DSS)-induced CAC.
|
25015995 |
2014 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Crhr1-deficient (Crhr1(-/-)) mice were used to explore the role of CRHR1 in the development of azoxymethane (AOM) and dextran sodium sulfate (DSS)-induced CAC.
|
25015995 |
2014 |
|
Alzheimer's Disease
|
0.060 |
Biomarker
|
disease |
BEFREE |
CRFR1 antagonism presents a viable disease-modifying therapy for AD, recommending its advancement to early-phase human safety trials.
|
26555315 |
2016 |
|
Linear atrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing hormone receptor 1 (CRH-R1) in the amygdala and the stria terminalis plays an important role in the activation of central stress circuits.
|
27497153 |
2016 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing factor receptor type 1 (CRF1R) is a class B receptor mediating stress response and also considered a drug target for depression and anxiety.
|
28183242 |
2017 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing factor receptor type 1 (CRF1R) is a class B receptor mediating stress response and also considered a drug target for depression and anxiety.
|
28183242 |
2017 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Corticotropin-releasing factor receptor type 1 (CRF1R) is a class B receptor mediating stress response and also considered a drug target for depression and anxiety.
|
28183242 |
2017 |
|
Anxiety Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
CRHR1 gene variation is associated with several mental disorders including anxiety disorders.
|
28233670 |
2017 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
CRHR1-KANSL1 was the most frequently identified fusion, identified in 6 tumors (2.7% of all tumors).
|
28423358 |
2017 |
|
Eating Disorders
|
0.020 |
Biomarker
|
group |
BEFREE |
CRF1 receptor antagonism may represent a novel pharmacological treatment for binge-related eating disorders.
|
28833350 |
2017 |
|
Carcinogenesis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
CRHR1 expression in human and dog corticotrophinomas suggested that this gene affects pituitary tumorigenesis.
|
29069262 |
2017 |