|
Anorexia
|
0.540 |
Biomarker
|
disease |
BEFREE |
CRF1 and CRF2 receptor antagonists suppressed VacA-induced anxiety and anorexia, respectively.
|
30979915 |
2019 |
|
Anorexia
|
0.540 |
GeneticVariation
|
disease |
BEFREE |
However, CRF(2) deletion abolished the prolonged phase of restraint-induced anorexia.
|
17953621 |
2007 |
|
Anorexia
|
0.540 |
Biomarker
|
disease |
CTD_human |
Thus, DIO rats showed signs of a preexisting, heritable deficit in the maintenance of postmeal satiety and a reduced sensitivity to anorectic CRF(2) agonist stimulation.
|
17627984 |
2007 |
|
Anorexia
|
0.540 |
Biomarker
|
disease |
BEFREE |
We hypothesized that urocortin 3 (UCN3) and corticotropin-releasing hormone receptor 2 (CRHR2) are associated with IMCL and subcutaneous fat depth (SFD), because the corticotropin-releasing hormone family of peptides are capable of strong anorectic and thermogenic effects.
|
17183713 |
2006 |
|
Anorexia
|
0.540 |
Biomarker
|
disease |
RGD |
Activation of the nociceptin/orphanin FQ system is unable to reverse CRF2 receptor mediated anorexia in the rat.
|
17050037 |
2006 |
|
Anorexia
|
0.540 |
AlteredExpression
|
disease |
BEFREE |
The present results also raise the possibility that leptin reduces food intake and b.w. at least partially due to the enhancement of the anorectic effect of CRH via increased PVN CRH expression and/or VMH CRHR-2 expression.
|
10223285 |
1999 |
|
Mental Depression
|
0.520 |
AlteredExpression
|
disease |
BEFREE |
TC-IBS showed a pronounced depression phenotype with increased corticotropin-releasing hormone receptor (CRHR)1 and CRHR2 expression at the frontal cortex and increased serum ACTH concentration.
|
31570003 |
2019 |
|
Mental Depression
|
0.520 |
Biomarker
|
disease |
RGD |
Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders.
|
20860876 |
2011 |
|
Mental Depression
|
0.520 |
Biomarker
|
disease |
PSYGENET |
Our results support an involvement of CRF receptors in the development of depression, such that elevated hippocampal CRF1 activity, in the absence of CRF2, produces a depression-dominated phenotype through the activation of the MEK/ERK pathway.
|
18843268 |
2009 |
|
Mental Depression
|
0.520 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to investigate the influence of genetic variants in CRHR1, CRHR2, CRH-BP and FKBP5 genes on both the vulnerability for depression and the response to antidepressant treatment.
|
17467808 |
2007 |
|
Mental Depression
|
0.520 |
Biomarker
|
disease |
PSYGENET |
Our aim was to investigate the influence of genetic variants in CRHR1, CRHR2, CRH-BP and FKBP5 genes on both the vulnerability for depression and the response to antidepressant treatment.
|
17467808 |
2007 |
|
Mental Depression
|
0.520 |
Biomarker
|
disease |
PSYGENET |
The resulting chimeric peptide, [Glu(21),Ala(40)][Svg(1-12)]x[human/rat CRF(14-30)]x[Svg(30-40)], named cortagine, was analyzed pharmacologically in cell culture by using human embryonic kidney-293 cells transfected with cDNA coding for CRF(1) or CRF(2), in autoradiographic experiments, and in behavior experiments using male C57BL/6J mice for its modulatory action on anxiety- and depression-like behaviors with the elevated plus-maze test and the forced swim test (FST), respectively.
|
15192151 |
2004 |
|
Mental Depression
|
0.520 |
Biomarker
|
disease |
PSYGENET |
Male and female CRFR2-mutant mice showed increased immobility as an indicator of depression compared with wild-type mice of the same sex.
|
12832554 |
2003 |
|
Anxiety Disorders
|
0.330 |
Biomarker
|
group |
BEFREE |
CRF1 and CRF2 receptor antagonists suppressed VacA-induced anxiety and anorexia, respectively.
|
30979915 |
2019 |
|
Anxiety Disorders
|
0.330 |
Biomarker
|
group |
BEFREE |
CRHR2-deficient mice display anxiety-like behavior, hypersensitivity to stress, altered feeding behavior and metabolism, and cardiovascular abnormalities.
|
16920976 |
2006 |
|
Anxiety Disorders
|
0.330 |
Biomarker
|
group |
BEFREE |
Two subtypes of the corticotropin-releasing factor (CRF) receptor, CRF(1) and CRF(2), differentially modulate brain functions such as anxiety and memory.
|
15192151 |
2004 |
|
Anxiety Disorders
|
0.330 |
Biomarker
|
group |
CTD_human |
Crhr2-mutant mice are hypersensitive to stress and display increased anxiety-like behaviour.
|
10742108 |
2000 |
|
Depressive disorder
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
TC-IBS showed a pronounced depression phenotype with increased corticotropin-releasing hormone receptor (CRHR)1 and CRHR2 expression at the frontal cortex and increased serum ACTH concentration.
|
31570003 |
2019 |
|
Hypertensive disease
|
0.320 |
Biomarker
|
group |
BEFREE |
Activation of corticotropin-releasing hormone (CRH) type 2 receptors (CRHR2) in the nucleus of the solitary tract (NTS) contributes to the development of hypertension, but the source of CRH inputs to the NTS that increases blood pressure remains unknown.
|
30565964 |
2019 |
|
Hypertensive disease
|
0.320 |
Biomarker
|
group |
BEFREE |
Collectively, these results suggest that CRHR2 in the NTS contributes to the IH-induced hypertension; downregulation of CRHR2 and CRHR2-mediated calcium influx in the NTS may serve as an adaptive response to protect against the IH-induced hypertension.
|
30354709 |
2018 |
|
Depressive disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Our results support an involvement of CRF receptors in the development of depression, such that elevated hippocampal CRF1 activity, in the absence of CRF2, produces a depression-dominated phenotype through the activation of the MEK/ERK pathway.
|
18843268 |
2009 |
|
Depressive disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Our aim was to investigate the influence of genetic variants in CRHR1, CRHR2, CRH-BP and FKBP5 genes on both the vulnerability for depression and the response to antidepressant treatment.
|
17467808 |
2007 |
|
Depressive disorder
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to investigate the influence of genetic variants in CRHR1, CRHR2, CRH-BP and FKBP5 genes on both the vulnerability for depression and the response to antidepressant treatment.
|
17467808 |
2007 |
|
Mood Disorders
|
0.320 |
Biomarker
|
group |
PSYGENET |
Dysfunctioning of corticotropin-releasing factor (CRF) and its receptors (CRF(1) and CRF(2)) has been linked to the development of stress-related disorders, such as affective disorders and drug abuse.
|
16611089 |
2006 |
|
Mood Disorders
|
0.320 |
Biomarker
|
group |
BEFREE |
Dysfunctioning of corticotropin-releasing factor (CRF) and its receptors (CRF(1) and CRF(2)) has been linked to the development of stress-related disorders, such as affective disorders and drug abuse.
|
16611089 |
2006 |