|
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clinical symptoms of septicemia, clinical outcome, and laboratory parameters of septicemia (C-reactive protein) were studied retrospectively in 66 patients with CONS septicemia.
|
10049985 |
1999 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Circulating concentrations of the sensitive inflammatory marker C-reactive protein (CRP) predict future cardiovascular events, and CRP is elevated during sepsis and inflammation, when vascular reactivity may be modulated.
|
15795363 |
2005 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, the diagnosis of sepsis is often based on the development of clinical signs, in combination with laboratory tests such as a rise in C-reactive protein (CRP).
|
19152691 |
2009 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
C-reactive protein (CRP) is widely used in early detection of sepsis or organ dysfunction.
|
20552244 |
2010 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Receiver operating characteristic curves showed that miR-15a had the highest area under the curve of 0.858 [95% confidence interval (CI) 0.800-0.916] for the diagnosis of sepsis compared with C reactive protein and procalcitonin with areas under the curve of 0.572 (95% CI 0.479-0.665; p=0.198) and 0.605 (95% CI 0.443-0.767; p=0.168), respectively.
|
22868808 |
2012 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Development was unremarkable apart from an episode labeled as sepsis with documented hyperkalemia and elevated C-reactive protein at age 15 days.
|
22968487 |
2012 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
178 biomarkers are described in the literature--ranging from specimen cultures, which lack sensitivity and specificity for early diagnosis of sepsis, to biomarkers such as C-reactive protein, procalcitonin, and genetic biomarkers, which have their own limitations.
|
23108494 |
2013 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The area under the ROC curve for MMP-8 in the diagnosis of sepsis was 0.87 (95% CI 0.82-0.92), and that of CRP was 0.98 (0.94-0.998), whereas the area of MMP-9 in the detection of non-septic state was 0.73 (0.65-0.80), p < 0.0001 for all curves.
|
24833564 |
2014 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic analysis found that individuals with the polymorphism of the FcγRIIa receptor that binds CRP poorly were also more likely to have decreased monocyte human leukocyte antigen DR and posttraumatic sepsis.
|
26496101 |
2015 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The area under ROC curve showed that the clinical accuracy of microRNA-25 for sepsis diagnosis was better than CRP and PCT (AUG=0.806, 0.676 and 0.726, P<0.05).The decrease in level of microRNA-25 was correlated with the severity of sepsis, SOFA score, CRP and PCT level, meanwhile, microRNA-25 level can be used for predicting the prognosis of patients, the patients with microRNA-25 level ≤0.492 had a lower 28 d survival rate.
|
26339334 |
2015 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The association of theses SNPs with the following parameters was evaluated: (1) the presence of sepsis; (2) severity and clinical outcomes; (3) APACHE II and SOFA scores; and (4) procalcitonin, C-reactive protein, tumor necrosis factor, lymphotoxin alpha, interleukin 1 beta and interleukin 10 plasma concentrations.
|
27592234 |
2016 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The levels of hemoglobin, white blood cell, platelet, lactate, and C-reactive protein were measured in the blood samples drawn from the patients with sepsis at diagnosis, at the 48th hour, and on day 7.
|
28167245 |
2017 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Six hours of polymicrobial sepsis elicited by cecal ligation and puncture (CLP) elevated serum C-reactive protein (CRP) (a bacteremia and sepsis marker) concentration in anesthetized and mechanically ventilated neonatal pigs.
|
27767365 |
2017 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum levels of calprotectin and C-reactive protein were significantly higher in patients with melioidosis and nonmelioidosis sepsis than in healthy controls.
|
28179407 |
2017 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In univariate analyses, higher age (p = 0.04), higher levels of C-reactive protein (p < 0.001), etiology of PRES (sepsis and chemotherapy; p = 0.02), altered coagulation (p = 0.002), altered mental state at onset (p = 0.03), and subarachnoid hemorrhage (SAH; p = 0.01) were related to in-hospital death.
|
27815684 |
2017 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
It was found that a history of relapse, a refractory state of underlying disease, and high C-reactive protein concentrations at the beginning of fever were significant risk factors for mortality after developing sepsis.
|
26055687 |
2017 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The univariate analysis showed gastrointestinal hemorrhage (P < 0.001), hepatic encephalopathy (P < 0.001), albumin <30 g/L (P < 0.037), creatinine (Cr) >175 µmol/L (P < 0.001), cholinesterase(ChE) activity <3000 U/L (P = 0.019), white blood cell count ≥10 000 (109/L) (P = 0.018), neutrophils ≥80% (P = 0.018), C-reactive protein (CRP) ≥25 mg/L (P < 0.001), procalcitonin ≥1.0 ng/mL (P = 0.007), Child-Pugh class C (P < 0.001), septicemia (P < 0.001), pulmonary infection (P < 0.001),multi-site infection (P = 0.001), acute-on-chronic liver failure (ACLF) (P < 0.001), and advanced hepatocellular carcinoma (HCC) (P < 0.001).
|
28249358 |
2017 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A high negative predictive value of CRP is also needed to rule out sepsis and bacterial infections in immunocompetent patients.
|
28735154 |
2017 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In both CKD1-4 and CKD5 patients, the predictive value of PCT for local infection is not as good as that of CRP, while it has a significant advantage in predicting sepsis.
|
28956241 |
2017 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
<b>Conclusion</b> The CRP levels and heart rate both decreased, while the pH and base excess parameters of the blood gas analysis changed positively after pentoxifylline treatment in VLBW preterm neonates with nosocomial sepsis.
|
28196391 |
2017 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of our study is to explore the value of soluble cluster of differentiation 14 subtype (sCD14-ST) in whole blood for differential diagnosis of neonatal hematosepsis at an early stage, and used in evaluation of the severity about sepsis combined with acute physiology and chronic health evaluation II (APACHE-II) score, procalcitonin (PCT), C reactive protein (CRP), and leukocyte (WBC).In our cohort, all cases met the diagnostic criteria for hematosepsis specific for newborns.
|
28471985 |
2017 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We concluded that CRP dosage at hospital admission is helpful to detect acute infection, and particularly sepsis, in geriatric patients, and that CRP elevation may provide valuable short-term prognostic information.
|
27594414 |
2017 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Median CRP, PCT and presepsin levels were significantly higher in patients with infection and sepsis.
|
27823951 |
2017 |
|
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The rs1764390 G allele is associated with increased susceptibility to sepsis, which may be involved in the process of sepsis via mediating the plasma levels of NO, IL-6 and CRP.
|
27939333 |
2017 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we examined the time course changes in the blood levels of HMGB1, C-reactive protein (CRP), procalcitonin (PCT) and serum amyloid A (SAA) in patients with secondary peritonitis who developed SIRS or sepsis.
|
28680349 |
2017 |