CRP, C-reactive protein, 1401

N. diseases: 1483; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE C-reactive protein levels reached a peak after 48 h. Patients with STEMI and signs of HF showed significantly higher peak CRP levels. 28883850 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE After adjusting for traditional risk factors, high-sensitivity C-reactive protein, N-terminal pro-B-type natriuretic peptide, and high-sensitivity cardiac troponin T, higher levels of Cp were associated with HF (hazard ratio, 1.44; 95% confidence interval, 1.13-1.83) and mortality (hazard ratio, 1.38; 95% confidence interval, 1.11-1.63). 23861484 2013
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE After beta-blocker treatment, hs-CRP levels are associated with functional capacity in HF patients. 29396658 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE After further adjustment for biomarkers (high-sensitivity C-reactive protein, lipoprotein-associated phospholipase A<sub>2</sub> activity, high-sensitivity troponin I, and B-type natriuretic peptide), IL-6 remained significantly associated with the risk of major adverse cardiovascular events (adj HR Q4:Q1 1.43, 95% CI 1.09-1.88) and cardiovascular death or heart failure (adj HR 1.79, 95% CI 1.22-2.63). 29066436 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE After multivariable adjustment for baseline clinical characteristics and established biomarkers (high-sensitivity troponin I, brain-type natriuretic peptide, and high-sensitivity C-reactive protein), FGF-23 concentration in the top quartile was independently associated with an increased risk of CV death or heart failure hospitalization (adjusted hazard ratio [HR], 2.35; 95% CI, 1.82-3.02; P < .001) and its individual components. 29710336 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE After multivariable adjustment for clinical variables and renal and CV biomarkers (estimated glomerular filtration rate, cystatin-C, urine albumin-to-creatinine ratio, FGF-23, high-sensitivity troponin T, N-terminal pro-B-type natriuretic peptide, and high-sensitivity C-reactive protein), low Klotho concentration remained strongly associated with increased risk of CV death or hospitalization for heart failure [adjusted hazard ratio (HR) 2.62; 95% confidence interval (CI) 1.35-5.08; P < 0.01]. 30773798 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE Age, chronic obstructive pulmonary disease (COPD), congestive heart failure (CHF), forced expiratory volume in one second/ forced vital capacity (FEV1/FVC) ratio, duration of operation, hemoglobin, albumin and C-reactive protein (CRP) were potential risk factors for PPCs by univariate analysis. 30003856 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE As a result, previous studies have not provided conclusive evidence of the prognostic value of CRP for post-infarct LVSD or HF. 29633232 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE Concerning death due to heart failure, NT-proBNP was associated with an 8-fold and C-reactive protein, GDF-15, and cystatin-C, with a 3-fold increase in risk. 30427997 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE Efficient electron-mediated electrochemical biosensor of gold wire for the rapid detection of C-reactive protein: A predictive strategy for heart failure. 31400725 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE Female gender, history of heart failure or left ventricular ejection fraction <40%, and high levels (>1 mg/dL) of C-reactive protein (CRP) were independently associated with left atrial SEC/thrombosis. 27730663 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE Further analysis revealed that MedDietScore differentially affected patients' prognosis according to heart failure phenotype, with short-term impact in HFrEF and HFmrEF patients yet longer positive outcomes in HFpEF and C-reactive protein potentially mediated these relations. 28832572 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 GeneticVariation disease BEFREE Furthermore, temporal changes in CRP levels were associated with cancer death in the overall cohort; HF patients with CRP ≥ 2.0 mg/L at both baseline and 1-year had significantly increased cancer death, while those with CRP ≥ 2.0 mg/L at baseline and < 2.0 mg/L at 1-year not. 31104823 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE Gold-nanorod enhances dielectric voltammetry detection of c-reactive protein: A predictive strategy for cardiac failure. 30716591 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE High CLA% was associated with significantly reduced risk of HF after adjustment for HF risk factors and C-reactive protein (hazard ratio [95% confidence interval], 0.64 [0.43-0.96]; quartile 4 versus quartile 1). 29306896 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE High-sensitivity C-reactive protein in chronic heart failure: patient characteristics, phenotypes, and mode of death. 31350553 2020
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE However, despite low arterial lactate, patients with a high APACHEⅡ score, high C-reactive protein levels, and chronic heart failure had a poorer prognosis. 28923305 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE However, the effect of CRP on heart failure has not been elucidated. 21519150 2011
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE In group 1, patients with a G/G genotype had significantly higher levels of high-sensitivity C-reactive protein and white blood cell counts, and much higher incidences of multi-vessel disease, greater lesion lengths, advanced congestive heart failure (>or=class 3) and 30-day mortality, than patients with G/A or A/A genotypes (p values<0.05 in all cases). 17652883 2007
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE In the multivariable analysis, higher vWF concentrations (middle tertile hazard ratio [HR] 4.59, 95% confidence interval [CI] 1.55-13.50 [P=0.006]; upper tertile HR 4.10, 95% CI 1.43-11.75 [P=0.009]), age≥75years (HR 5.02, 95% CI 1.53-16.49; P=0.008), heart failure (HR 2.05, 1.01-4.19; P=0.048), C-reactive protein, log<sub>2</sub> per unit increase (HR 1.29, 95% CI 1.04-1.61; P=0.021), no warfarin at discharge (HR 4.96, 95% CI 2.02-12.20; P<0.0001) and no aspirin at discharge (HR 4.41, 95% CI 1.71-11.97; P=0.002) were independently associated with an increased risk of stroke and all-cause death, whereas female sex was a protective factor (HR 0.35, 0.16-0.78; P=0.01). 29685722 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE In the multivariable analysis, the independent predictors of death were age (odds ratio (OR) 1.07, 95% confidence interval (CI) 1.02-1.13), C-reactive protein (CRP) at hospital admission (OR 1.12, 95% CI 1.04-1.21), length of the vegetation at diagnosis (OR 1.15, 95% CI 1.03-1.28), development of heart failure (OR 6.43, 95% CI 2.14-19.33), and embolic events during antimicrobial therapy (OR 12.14, 95% CI 2.11-71.89). 29382606 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE In this study we investigated distribution of CRP, the Terminal Complement Complex (C5b-9) and macrophages (CD68) in the myocardium of patients suffering from non-ischaemic heart failure and their implication on clinical parameters. 19343415 2009
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE Longitudinal patterns of N-terminal pro B-type natriuretic peptide, troponin T, and C-reactive protein in relation to the dynamics of echocardiographic parameters in heart failure patients. 31596459 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 Biomarker disease BEFREE Older age, atrial fibrillation, hypertension, obesity, edema, high C-reactive protein, and smoking were risk factors for HF. 29934374 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 GeneticVariation disease BEFREE Other predictors included ischemic etiology (HR 1.33, p=0.023), prior hospitalization for heart failure (HR 1.34, p=0.017), C-reactive protein (HR 1.04, p<0.001), and statin use (HR 0.70, p=0.016). 29169753 2018