CRP, C-reactive protein, 1401

N. diseases: 1483; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE When normalized to sampling time from stroke occurrence, both cholinergic parameters were correlated with multiple inflammatory biomarkers, including fibrinogen, interleukin-6 and C-reactive protein (r=0.713, r=0.607; r=0.421, r=0.341; r=0.276, r=0.255; respectively; all P values<0.001). 20464061 2010
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 AlteredExpression group BEFREE Although elevated levels of C-reactive protein (CRP) independently predict increased risk of development of metabolic syndrome, diabetes, myocardial infarction, and stroke, comprehensive analysis of the influence of genetic variation on CRP is not available. 18439548 2008
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Blood samples collected at 24 h after stroke symptom onset were used to measure the inflammatory biomarkers of glycoprotein IIb (CD41) expressing microparticles (MP), C-reactive protein (CRP), COX 2, APOE, and Angiopoietin 1. 28275651 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE The addition of CRP with eosinophil and/or neutrophil count significantly improved a base model for the prediction of mortality which included age, gender, race/ethnicity, body mass index, smoking, poverty income ratio, asthma, diabetes, hypertension and history of stroke or myocardial infarction. 29227024 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 GeneticVariation group BEFREE The combination of the 2 minor alleles of C-reactive protein (CRP; 3'UTR 1846C/T) and interleukin-6 (IL-6; -174G/C) polymorphisms, occurring in 583 (35.7%) patients, was significantly associated with stroke (odds ratio, 3.3; 95% CI, 1.4 to 8.1; P=0.0023). 16051899 2005
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Relationship between high-sensitivity C-reactive protein and early neurological deterioration in stroke patients with and without atrial fibrillation. 31699451 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 AlteredExpression group BEFREE Serum levels of TNF-α, C-reactive protein (CRP), IL-4, IL-6, IL-10, IL-17, IL-23, and TGF-β increased, whereas serum level of IFN-γ decreased at all time points after stroke. 27682880 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 GeneticVariation group BEFREE C-reactive protein levels and genetic variants of CRP as prognostic markers for combined cardiovascular endpoint (cardiovascular death, death from stroke, myocardial infarction, and stroke/TIA). 27580453 2016
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 GeneticVariation group BEFREE However, during the acute phase of stroke/TIA, individuals with the AG/GG genotype had significantly elevated CRP concentrations as opposed to those with the AA genotype (2.02 +/- 1.59 vs. 1.73 +/- 1.69 mg/l, P = 0.027). 17355554 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE In the multivariable analysis, higher vWF concentrations (middle tertile hazard ratio [HR] 4.59, 95% confidence interval [CI] 1.55-13.50 [P=0.006]; upper tertile HR 4.10, 95% CI 1.43-11.75 [P=0.009]), age≥75years (HR 5.02, 95% CI 1.53-16.49; P=0.008), heart failure (HR 2.05, 1.01-4.19; P=0.048), C-reactive protein, log<sub>2</sub> per unit increase (HR 1.29, 95% CI 1.04-1.61; P=0.021), no warfarin at discharge (HR 4.96, 95% CI 2.02-12.20; P<0.0001) and no aspirin at discharge (HR 4.41, 95% CI 1.71-11.97; P=0.002) were independently associated with an increased risk of stroke and all-cause death, whereas female sex was a protective factor (HR 0.35, 0.16-0.78; P=0.01). 29685722 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 AlteredExpression group BEFREE Modified C-reactive protein is expressed by stroke neovessels and is a potent activator of angiogenesis in vitro. 19170684 2010
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 GeneticVariation group LHGDN Triggered C-reactive protein (CRP) concentrations and the CRP gene -717A>G polymorphism in acute stroke or transient ischemic attack. 17355554 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 AlteredExpression group LHGDN We sought to investigate the relationship between high-sensitivity C-reactive protein (CRP) levels and the risk of further ischemic events in first-ever transient ischemic attack (TIA) or stroke patients with intracranial large-artery occlusive disease. 14500938 2003
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE The most consistent association was found between C-reactive protein (CRP) and CE strokes when compared to other stroke subtypes (standardized mean difference 0.223 (0.116, 0.343); p < 0.001) Conclusions: Our findings confirm a possible association between selected inflammatory biomarkers and CE stroke. 28117601 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Elevated C-reactive protein increases diagnostic accuracy of algorithm-defined stroke-associated pneumonia in afebrile patients. 30196790 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 AlteredExpression group LHGDN We investigated whether levels of C-reactive protein (CRP) and fibrinogen are increased in patients with acute stroke and SA compared with stroke patients without SA. 17878721 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE CRP has a significant direct, yet weak, correlation to the severity of stroke. 30991382 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 GeneticVariation group BEFREE The AHEI-2010 was inversely associated with stroke (HR 0.66; 95% CI 0.42, 0.88) incidence, aortic pulse wave velocity, and C-reactive protein. 28293738 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Complement C3 and C-reactive protein are elevated in South Asians independent of a family history of stroke. 16809564 2006
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 GeneticVariation group BEFREE Genetic variation in the CRP gene is associated with microangiopathic but not macroangiopathic or cardioembolic stroke in a large German stroke sample. 20733302 2010
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE High-sensitivity C-reactive protein in stroke patients - The importance in consideration of influence of multiple factors in the predictability for disease severity and death. 27825611 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 AlteredExpression group LHGDN The serum high-sensitive C reactive protein and homocysteine levels to evaluate the prognosis of acute ischemic stroke. 17597836 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Using CRP and T3 as prognostic factors resulted in a probability of 53.5% to predict a poor functional outcome and of 80.42% to predict a poor cognitive outcome in stroke patients at discharge. 30056003 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 GeneticVariation group LHGDN The combination of the 2 minor alleles of C-reactive protein (CRP; 3'UTR 1846C/T) and interleukin-6 (IL-6; -174G/C) polymorphisms, occurring in 583 (35.7%) patients, was significantly associated with stroke (odds ratio, 3.3; 95% CI, 1.4 to 8.1; P=0.0023). 16051899 2005
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Potential indirect associations of high-sensitivity C-reactive protein and the Framingham Stroke Risk Profile also were examined. 28437380 2018