|
Cerebrovascular accident
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These findings may explain the link between elevated C-reactive protein levels and the risk of cardiovascular disease and stroke but should be reproduced in a larger cohort.
|
11739967 |
2001 |
|
Cerebrovascular accident
|
0.100 |
AlteredExpression
|
group |
LHGDN |
We sought to investigate the relationship between high-sensitivity C-reactive protein (CRP) levels and the risk of further ischemic events in first-ever transient ischemic attack (TIA) or stroke patients with intracranial large-artery occlusive disease.
|
14500938 |
2003 |
|
Cerebrovascular accident
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The combination of the 2 minor alleles of C-reactive protein (CRP; 3'UTR 1846C/T) and interleukin-6 (IL-6; -174G/C) polymorphisms, occurring in 583 (35.7%) patients, was significantly associated with stroke (odds ratio, 3.3; 95% CI, 1.4 to 8.1; P=0.0023).
|
16051899 |
2005 |
|
Cerebrovascular accident
|
0.100 |
GeneticVariation
|
group |
LHGDN |
The combination of the 2 minor alleles of C-reactive protein (CRP; 3'UTR 1846C/T) and interleukin-6 (IL-6; -174G/C) polymorphisms, occurring in 583 (35.7%) patients, was significantly associated with stroke (odds ratio, 3.3; 95% CI, 1.4 to 8.1; P=0.0023).
|
16051899 |
2005 |
|
Cerebrovascular accident
|
0.100 |
Biomarker
|
group |
LHGDN |
C-reactive protein and cerebral small-vessel disease: an opportunity to reassess small-vessel disease physiopathology?
|
16087807 |
2005 |
|
Cerebrovascular accident
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Because serum levels of IL-6 and CRP are independent risk factors for stroke and myocardial infarction (MI), we investigated whether Cpn burden in carotid plaques might provide a link between plaque IL-6 expression and elevated serum levels of IL-6 and CRP.
|
16210572 |
2005 |
|
Cerebrovascular accident
|
0.100 |
Biomarker
|
group |
BEFREE |
Complement C3 and C-reactive protein are elevated in South Asians independent of a family history of stroke.
|
16809564 |
2006 |
|
Cerebrovascular accident
|
0.100 |
Biomarker
|
group |
BEFREE |
We sought to investigate whether CRP measured before tissue plasminogen activator (tPA) treatments may add prognostic information to guide stroke thrombolysis.
|
16601211 |
2006 |
|
Cerebrovascular accident
|
0.100 |
GeneticVariation
|
group |
BEFREE |
However, during the acute phase of stroke/TIA, individuals with the AG/GG genotype had significantly elevated CRP concentrations as opposed to those with the AA genotype (2.02 +/- 1.59 vs. 1.73 +/- 1.69 mg/l, P = 0.027).
|
17355554 |
2007 |
|
Cerebrovascular accident
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Triggered C-reactive protein (CRP) concentrations and the CRP gene -717A>G polymorphism in acute stroke or transient ischemic attack.
|
17355554 |
2007 |
|
Cerebrovascular accident
|
0.100 |
AlteredExpression
|
group |
LHGDN |
We investigated whether levels of C-reactive protein (CRP) and fibrinogen are increased in patients with acute stroke and SA compared with stroke patients without SA.
|
17878721 |
2007 |
|
Cerebrovascular accident
|
0.100 |
AlteredExpression
|
group |
LHGDN |
The serum high-sensitive C reactive protein and homocysteine levels to evaluate the prognosis of acute ischemic stroke.
|
17597836 |
2007 |
|
Cerebrovascular accident
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Although elevated levels of C-reactive protein (CRP) independently predict increased risk of development of metabolic syndrome, diabetes, myocardial infarction, and stroke, comprehensive analysis of the influence of genetic variation on CRP is not available.
|
18439548 |
2008 |
|
Cerebrovascular accident
|
0.100 |
Biomarker
|
group |
BEFREE |
Concentration exceeding 2 mg/l represents an increased individual risk of myocardial infarction and stroke but strict application of this borderline is complicated by relations of CRP concentrations to other risk factors of cardiovascular diseases.
|
20131929 |
2009 |
|
Cerebrovascular accident
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We collected conventional (blood pressure, cholesterol, adiposity), lifestyle, and novel (C-reactive protein, CRP) risk factors at baseline in participants from the Scottish Health Surveys (n = 5946, 44.5% men, aged 53.6 +/- 12.4 years), who were followed up over an average of 7.1 years for cardiovascular disease (CVD) events (a composite of fatal and nonfatal events incorporating acute myocardial infarction, coronary artery bypass surgery, percutaneous coronary angioplasty, stroke, heart failure).
|
19587606 |
2009 |
|
Cerebrovascular accident
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A secondary aim was to study the relationship between the 1444C>T polymorphism, plasma levels of CRP and stroke.
|
19390179 |
2009 |
|
Cerebrovascular accident
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Neither CRP genotypes nor haplotypes showed an association with hemorrhagic stroke.
|
19262552 |
2009 |
|
Cerebrovascular accident
|
0.100 |
Biomarker
|
group |
BEFREE |
When normalized to sampling time from stroke occurrence, both cholinergic parameters were correlated with multiple inflammatory biomarkers, including fibrinogen, interleukin-6 and C-reactive protein (r=0.713, r=0.607; r=0.421, r=0.341; r=0.276, r=0.255; respectively; all P values<0.001).
|
20464061 |
2010 |
|
Cerebrovascular accident
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Modified C-reactive protein is expressed by stroke neovessels and is a potent activator of angiogenesis in vitro.
|
19170684 |
2010 |
|
Cerebrovascular accident
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic variation in the CRP gene is associated with microangiopathic but not macroangiopathic or cardioembolic stroke in a large German stroke sample.
|
20733302 |
2010 |
|
Cerebrovascular accident
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Although these variants and corresponding haplotypes in the CRP gene are associated with serum CRP concentrations, our study does not support that variants and corresponding haplotypes studied here have a major influence on risk of stroke and stroke recurrence.
|
20184533 |
2010 |
|
Cerebrovascular accident
|
0.100 |
Biomarker
|
group |
BEFREE |
In participant data from the Wandsworth Heart and Stroke Study including European, South Asian and African, and Caribbean-descent subjects, body mass index, systolic blood pressure, and smoking contributed to between-group differences in CRP, but the majority of the difference in CRP was unexplained.
|
20876875 |
2010 |
|
Cerebrovascular accident
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In a small, preliminary study, patients at risk of stroke (multiple risk factors for stroke, with chronically elevated C-reactive protein, but negative MRI for brain pathology) exhibited increased inflammation in the brain, as indicated by PET imaging.
|
21356305 |
2011 |
|
Cerebrovascular accident
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, CRP can be a good target for drug discovery to prevent disease pathogenesis, especially cardioprotection in acute myocardial infarction and neuroprotection in stroke.
|
21541851 |
2011 |
|
Cerebrovascular accident
|
0.100 |
Biomarker
|
group |
BEFREE |
In the recently completed JUPITER trial, men and women without prior cardiovascular disease or diabetes who had baseline low-density lipoprotein cholesterol <130 mg/dL and high-sensitivity C-reactive protein ≥ 2 mg/L were randomly allocated to rosuvastatin 20 mg daily or to placebo and followed for first major vascular events (nonfatal myocardial infarction, nonfatal stroke, hospitalization for unstable angina, arterial revascularization, or vascular death) and for all-cause mortality.
|
21493817 |
2011 |