CRP, C-reactive protein, 1401

N. diseases: 1483; N. variants: 15
Disease: Major Depressive Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE Here, we compared the concentrations of c-reactive protein (CRP) and kynurenine pathway metabolites in a combined sample of subjects with major depressive disorder (MDD), bipolar disorder (BD), and healthy controls (HC) comprising 130 men and 350 women. 28867283 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE C-reactive protein was increased in non-melancholic MDD in 2 out of 4 studies, while there was no difference for tumor necrosis factor-α and interleukin-2 and 10. 29935756 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE Additionally, our findings suggest a causal relationship between increased inflammation and high cholesterol in depression, as a single infusion of infliximab reduced cholesterol in TRD patients with high CRP compared to placebo. 30249443 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE A consistent body of research has confirmed that patients with major depressive disorder (MDD) have increased concentrations of pro-inflammatory cytokines, including IL-6, TNF-α, IL-1β, the soluble IL-2 receptor, and C-reactive protein, compared to controls; however, there is limited information on IL-17A in MDD. 29069253 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 AlteredExpression disease BEFREE Baseline CRP levels relate differentially to antidepressant treatment outcomes in persons with major depressive disorder. 28187400 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE This study aimed to a) examine IR and β-cell function as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) and insulin sensitivity and β cell function (HOMA-B) and glucotoxicity (conceptualized as increased glucose levels versus lowered HOMA-B values) in 74 participants with major depressive disorder (MDD) and bipolar disorder, with and or without MetS and TUD, versus 46 healthy controls, and b) whether IR is associated with IO&NS biomarkers, including nitric oxide metabolites (NOx), lipid hydroperoxides (LOOH), plasma advanced oxidation protein products (AOPP), C-reactive protein (CRP), haptoglobin (Hp) and uric acid. 28710952 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE Association between C-reactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression. 28257825 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 GeneticVariation disease BEFREE To determine whether subgroups of patients with MDD stratified according to the A/W criterion had a different degree of genetic overlap with obesity-related traits (body mass index [BMI] and levels of C-reactive protein [CRP] and leptin). 29049554 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 AlteredExpression disease BEFREE Agomelatine's antidepressant properties were associated with a reduction in circulating CRP levels in MDD patients who achieved remission after 12 weeks of treatment. 27702411 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 AlteredExpression disease BEFREE We aimed to explore the roles of NLR, C-reactive protein (CRP) and serum lipid levels on suicidal behavior in patients with MDD. 28800269 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE Higher observed CRP and AA, their mutual association, and relation with amygdala-reactivity, are corroborative with a role for (neuro)inflammation in MDD. 28262603 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 AlteredExpression disease BEFREE Patients with MD exhibited higher levels of CRP, higher neutrophil and monocyte counts, lower IL-10 levels and reduced LPS-stimulated IL-6 production compared to controls (P<0.001-0.045). 28509904 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE Conclusions The level of CRP plays a role of biomarker to differentiate between MDD and BD II depression in both their depressed and euthymic state. 26895280 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 GeneticVariation disease BEFREE Genetic overlap of MDD and subtypes with psychiatric (MDD, bipolar disorder, schizophrenia) and metabolic (body mass index (BMI), C-reactive protein, triglycerides) traits was evaluated via genomic profile risk scores (GPRS) generated from meta-analysis results of large international consortia. 26122587 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease PSYGENET Here we examined circulating concentrations of inflammatory cytokines (IFN-γ, TNF-α, IL-1β, IL-6), and the acute phase protein CRP alongside plasma tryptophan, kynurenine, kynurenic acid (KYNA) and 3-hydroxyanthranilic acid (3-HAA) concentrations, and whole blood mRNA expression of IDO, kynurenine aminotransferases (KAT I and II), kynurenine-3-monooxygenase (KMO), kynureninase and SERT in patients with major depressive disorder (MDD) compared with age and sex-matched controls. 22683764 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease PSYGENET A multimodal approach with structural neuroimaging of hippocampus and amygdala, measurement of peripheral inflammatory proteins interleukin (IL)-6 and C-reactive protein (CRP), glucocorticoid receptor (GR) mRNA expression, and expression of glucocorticoid-inducible genes (glucocorticoid-inducible genes Leucin Zipper (GILZ) and glucocorticoid-inducible kinase-1 (SGK-1)) was used in 40 patients with MDD and 43 healthy controls (HC). 22832853 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 AlteredExpression disease BEFREE Here we examined circulating concentrations of inflammatory cytokines (IFN-γ, TNF-α, IL-1β, IL-6), and the acute phase protein CRP alongside plasma tryptophan, kynurenine, kynurenic acid (KYNA) and 3-hydroxyanthranilic acid (3-HAA) concentrations, and whole blood mRNA expression of IDO, kynurenine aminotransferases (KAT I and II), kynurenine-3-monooxygenase (KMO), kynureninase and SERT in patients with major depressive disorder (MDD) compared with age and sex-matched controls. 22683764 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease BEFREE Patients with MDD showed smaller hippocampal volumes and increased inflammatory proteins IL-6 and CRP compared with HC. 22832853 2012