|
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Compared to HC, all MDD exhibited a stronger positive association between CRP and coupling between activity in striatum and inferred food pleasantness.
|
31604141 |
2020 |
|
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The present findings suggest that major depression is frequent in SZ patients and that increased CRP levels are associated with non-remission under antidepressants in this population.
|
31676465 |
2020 |
|
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study aimed to examine the serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP) in MDD patients to find out their association with depression.
|
30899619 |
2019 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
While cross-sectional associations of inflammatory markers interleukin-6 (IL-6) and C-reactive protein with major depressive disorder are well established, evidence for longitudinal associations mostly comes from studies on depression symptoms, not diagnoses.
|
30819515 |
2019 |
|
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Blood serum concentration of several products known to be synthesized by activated microglia (and to some extent astroglia) [prostaglandin E<sub>2</sub> (PGE<sub>2</sub>), prostaglandin F<sub>2</sub> alpha (PGF<sub>2α</sub>), and tumor necrosis factor alpha (TNF<sub>α</sub>)], controlled by an index of peripheral inflammation [C-reactive protein (CRP)] and TSPO V<sub>T</sub> were measured in 3 cohorts: prefrontal cortex TSPO V<sub>T</sub> of 20 subjects with major depressive episodes (MDEs) from major depressive disorder (MDD); and 56 subjects with treatment resistant MDEs from MDD; and dorsal caudate TSPO V<sub>T</sub> of 20 subjects with obsessive-compulsive disorder.
|
31683271 |
2019 |
|
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we assessed the differences in serum levels of interleukin 6 (IL-6) and interleukin 8 (IL-8) as well as C-reactive protein (CRP) in patients with MDD and BD.
|
30762747 |
2019 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
<b>Results:</b> Collectively, the literature and original data showed that: 1) raised serum levels of pro-inflammatory compounds (in particular of CRP/IL-6) characterize an inflammatory form of MDD with poor responsiveness to predominately serotonergic agents, but a better responsiveness to antidepressant regimens with a) (add-on) noradrenergic, dopaminergic, or glutamatergic action or b) (add-on) anti-inflammatory agents such as infliximab, minocycline, or eicosapentaenoic acid, showing-next to anti-inflammatory-dopaminergic or lipid corrective action; 2) these successful anti-inflammatory (add-on) agents, when used in patients with low serum levels of CRP/IL-6, decreased response rates in comparison to placebo.
|
31354538 |
2019 |
|
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
CRP was elevated in patients with MDD, and more so in treatment-resistant patients.
|
29764522 |
2019 |
|
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Baseline serum CRP levels may predict antidepressant treatment responses in patients with MDD and patients with higher levels of CRP were less likely to get remission.
|
30878656 |
2019 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Multivariate logistic regression analysis revealed that male sex, high blood pressure, hypertriglyceridemia, BMI ≥30kg/m², age ≥50 years, sleep duration <6.5 hours, C-reactive protein ≥4.5mg/L, Beck Depression Inventory >12, and apnea-hypopnea index ≥5/h were significant risk factors of type 2 diabetes in major depression.
|
29246639 |
2019 |
|
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Accumulating evidence has confirmed the association between chronic inflammation and MDD, which is manifested by increased levels of the C-reactive protein, as well as pro-inflammatory cytokines, such as Interleukin 1 beta, Interleukin 6, and the Tumor necrosis factor alpha.
|
31075818 |
2019 |
|
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The main objective of the current study was to understand how CRP was related to trauma, dissociation, PTSD and MDD in a sample of 55 traumatized African American women with type 2 diabetes mellitus recruited from an urban hospital.
|
31306866 |
2019 |
|
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
C-reactive protein, diet quality and physical activity did not mediate the effect of obesity on major depressive disorder, and C-reactive protein mediated about 25% of the effect of major depressive disorder on adiposity.
|
31800914 |
2019 |
|
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
CRP, DII, and WBC were associated with MD.No associations were found for IgE.
|
30699847 |
2019 |
|
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the relationship between quality of life (QoL) (physical and mental health, assessed by the SF-36) and chronic inflammation assessed using C-reactive protein (CRP) in patients with current major depressive disorder.
|
29156363 |
2018 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The CRP locus (rs3093077) showed a similar level of evidence for interaction in the meta-analysis (RD=0.092, SE=0.029, p=0.002), but less compelling evidence in the replication sample alone (recurrent MDD q=0.198; all MDD q=0.126).
|
28867280 |
2018 |
|
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
There was no evidence that MDD was associated with the level of CRP titres [aOR = 0.95 (0.78-1.15); p = 0.60)].
|
29298663 |
2018 |
|
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased plasma nesfatin-1 levels may be associated with corticosterone, IL-6, and CRP levels in patients with major depressive disorder.
|
29427582 |
2018 |
|
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
MDD was associated with Metabolic syndrome (31.4 v. 20.2%; P = 0.006) but not with increased C-reactive protein.
|
29871707 |
2018 |
|
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Prior studies suggest that the inflammatory biomarker c-reactive protein (CRP) holds promise for predicting antidepressant response in patients with major depressive disorder.
|
30102967 |
2018 |
|
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, MDD patients showed higher levels of IL-6 and a trend for higher CRP levels, which were also associated with similar alterations in the serum N-glycan profile as those characteristic for MDD patients.
|
29529546 |
2018 |
|
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study proposes to measure blood C-reactive protein (CRP) levels before the initiation of treatment in 200 participants with MDD.
|
30126458 |
2018 |
|
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Key messages An increasing OR for MDD was demonstrated with regard to health status such as CVD, chronic respiratory tract disease, arthritis, thyroid problems, lower eGFR, fair or poor self-rated health condition, and elevated CRP level.
|
30311809 |
2018 |
|
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
CRP appears to be a peripheral biomarker that reflects peripheral and central inflammation and seems well-suited for guiding immunotherapies targeting TNF and IL-6 in patients with MDD.
|
29895893 |
2018 |
|
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study examined circulating concentrations of C-reactive protein (CRP), plasma tryptophan, kynurenine (KYN), kynurenic acid (KYNA) and quinolinic acid (QUIN) and whole blood mRNA expression of IDO in patients with major depressive disorder (MDD) compared with healthy controls (HC).
|
29787958 |
2018 |