|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
A complete clinical assessment, assessment of vascular risk factors, blood sample for the evaluation of serum CRP was obtained, and baseline depression severity was measured on Hamilton Depression Rating Scale (HDRS).
|
30581212 |
2020 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
There were no longitudinal associations between DGIH/BMI and depression, and adjustment for IL-6 and C-reactive protein did not attenuate associations between IR/BMI and depression; however, the longitudinal analyses may have been underpowered.
|
30854996 |
2020 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The specific aim of this study was to explore the relationships between biomarkers of neural health: nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), immune health: interleukin 6 (IL-6), c-reactive protein (CRP), and cortisol, as well as the presence of depression, in physically active cannabis users (CU) and non-users (NU).
|
31319037 |
2020 |
|
Depressed mood
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
We have examined whether longitudinal patterns of inflammation, based on three CRP measurements from childhood to early-adulthood, are associated with the risk of depression in early-adulthood in the Avon Longitudinal Study of Parents and Children, a prospective birth cohort.
|
31707310 |
2020 |
|
Depressed mood
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Depressive symptoms were associated with CRP levels, providing supporting evidence for the role of inflammation in the pathophysiology of depression.
|
30958417 |
2019 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The depression sum-score was related to both IL-6 and CRP before, and only to IL-6 after covariate adjustment.
|
31615595 |
2019 |
|
Depressed mood
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Participants with a high CRP levels had a significantly higher rate of depression than did those with a low hs-CRP levels (25.1% vs. 19.8%, p = 0.007).
|
31377557 |
2019 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
After additionally controlling for physical activity, elevated WBC count (p = 0.002) and decreased levels of urine cortisol (p = 0.05) remained significant predictors of PTSD course, and elevated WBC count (p = 0.001), CRP (p = 0.03), and fibrinogen (p = 0.02) remained significant predictors of depression course.
|
30389462 |
2019 |
|
Depressed mood
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
CRP SNPs rs1800947 and rs2794521 may be associated with depressive symptoms in patients with depression in a sexspecific fashion.
|
31711279 |
2019 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Although previous data indicate that dyadic coping is associated with Hypothalamic-Pituitary-Adrenal (HPA-axis and C-reactive protein (CRP) separately, no study has reported on the ratio between these two systems and dyadic coping, despite this index of physiological homeostasis being associated with physical health and depression.
|
31479683 |
2019 |
|
Depressed mood
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
These effects were fully attenuated by five serum proteins: AGE: Insulin-like Growth Factor-Binding Protein 2 (IGF-BP2), Epidermal Growth Factor Receptor 1 (EGFR); Depression: Resistin; Gender: Thrombopoeitin (THPO); APOE: C-Reactive Protein (CRP).
|
31665233 |
2019 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
After adjusting for age, gender, BMI, smoking, and dyslipidemia-inducing antipsychotics, TC and LDL scores showed significant associations with depression [β = 0.13, p = 0.007; β = 0.14, p = 0.007], and with two inflammatory markers: CRP [β = 0.14, p = 0.007; β = 0.16, p = 0.007] and OPG [β = 0.14, p = 0.007; β = 0.11, p = 0.007].
|
29721726 |
2019 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The associations between baseline log CRP and depression response and remission were also assessed.
|
29654412 |
2019 |
|
Depressed mood
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
After adjustment for demographics, health indicators, and medication use, increased plasma CRP levels were more strongly associated with late-onset depression than early-onset depression (OR [95% CI]: 1.43 [1.05-1.94]).
|
30172071 |
2019 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
When stratifying by zygosity, significant associations from IL-6 to depression were only seen in monozygotic twins, but associations from depression to CRP were more robust in dizygotic twins, which implies that genetic factors may play a role in this association.
|
30394311 |
2019 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Mediation analysis found that lower CRP partially mediated less depression in EGFR mutant NSCLC.
|
31022775 |
2019 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
IL-6, CRP and triglycerides are likely to be causally linked with depression, so could be targets for treatment and prevention of depression.
|
30886334 |
2019 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Hierarchical regression analyses (controlling for sex, age and the shared variance of risk and resilience factors) showed that (i) cognitive depression was significantly predicted by negative self-judgement and reduced cognitive empathy; (ii) abundance of Lactobacillus spp. was directly related to positive self-judgement but only indirectly to cognitive depression and lower affective empathy (both through self-judgement); and (iii) CRP was the strongest predictor of reduced cognitive empathy, with suppression effects seen for age (negative) and IL-6 (positive) after controlling for CRP.
|
30955108 |
2019 |
|
Depressed mood
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Controlling for inflammatory activity at BD1, depression at BD1, demographics and the time between assessments, increases in interleukin-6 (IL-6; b = 0.878, p = .007) and C-reactive protein (CRP; b = 0.252, p = .024) from BD1 to BD2 interacted with recent stressful life events before BD1 to predict severity of depressive symptoms at BD2.
|
30822466 |
2019 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Sex Difference in the Association between High-sensitivity C-reactive Protein and Depression: The 2016 Korea National Health and Nutrition Examination Survey.
|
30760746 |
2019 |
|
Depressed mood
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
In total, physical function (J-HAQ, grip power, DASH, TUG, JSSF), quality of life (J-HAQ, General Health, EQ-5D) and depression (BDI-II) improved and disease activity (CRP, DAS28-CRP(4)) decreased significantly 6 and 12 months after surgery (p<.01), despite some differences in their outcomes by the preoperative disease activity and the surgical site.
|
29575958 |
2019 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
This study aimed to examine the serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP) in MDD patients to find out their association with depression.
|
30899619 |
2019 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
In women, there was no association between CRP and telomere length, regardless of the depression status.
|
31109116 |
2019 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
In contrast, C-reactive protein was not associated with current depression in cross-sectional and longitudinal analyses.
|
30819515 |
2019 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Receiver operating characteristic analysis indicated that CRP had moderate predictive accuracy in identifying elevated depression (area under the curve = 0.74).
|
30521079 |
2019 |