CRY1, cryptochrome circadian regulator 1, 1407

N. diseases: 91; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.330 GeneticVariation disease BEFREE Our aim was to study SDPR, PRKCDBP, CRY1 and CRY2 genetic variants in depressive disorders. 27721187 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.330 Biomarker disease PSYGENET The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression. 22538398 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.330 Biomarker disease PSYGENET Circadian rhythm disturbance has been implicated in depression, and polymorphisms of circadian genes Cry1, Cry2, and Tef are associated with depression. 23138696 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.330 GeneticVariation disease BEFREE The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression. 22538398 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.330 GeneticVariation disease BEFREE Circadian rhythm disturbance has been implicated in depression, and polymorphisms of circadian genes Cry1, Cry2, and Tef are associated with depression. 23138696 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease PSYGENET The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression. 22538398 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease PSYGENET We examined 209 single-nucleotide polymorphisms (SNPs) covering 19 circadian genes (ADCYAP1, ARNTL, ARNTL2, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1E, DBP, NPAS2, NR1D1, PER1, PER2, PER3, RORA, TIMELESS, VIP, and VIPR2) in a sample of 534 MD patients (335 with unipolar major mood depression (MDD) and 199 with bipolar disorder (BD)) and 440 community-based screened controls. 20072116 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease BEFREE Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. 20072116 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease BEFREE One of the human circadian clock genes, cryptochrome 1 (Cry1) (located on 12q23-q24.1) was analyzed because of its close correspondence to a linkage hotspot for bipolar disorder. 15722957 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease PSYGENET Linkage disequilibrium analyses using single SNPs and haplotypes showed no association to bipolar disease.Additional, more powerful, studies involving Cry1 and other circadian clock genes need to be tested before an association of circadian abnormalities with bipolar disorder can be excluded. 15722957 2005
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.310 GeneticVariation disease BEFREE Circadian rhythm disturbance has been implicated in depression, and polymorphisms of circadian genes Cry1, Cry2, and Tef are associated with depression. 23138696 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.310 Biomarker disease PSYGENET Circadian rhythm disturbance has been implicated in depression, and polymorphisms of circadian genes Cry1, Cry2, and Tef are associated with depression. 23138696 2012
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.310 Biomarker disease PSYGENET The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression. 22538398 2012
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.310 GeneticVariation disease BEFREE The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression. 22538398 2012
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.300 Biomarker disease CTD_human Downregulation of circadian clock genes in chronic myeloid leukemia: alternative methylation pattern of hPER3. 16999817 2006
CUI: C0393770
Disease: Delayed Sleep Phase Syndrome
Delayed Sleep Phase Syndrome 		0.300 Biomarker disease CTD_human
CUI: C0494410
Disease: Nonorganic Sleep Wake Cycle Disorders
Nonorganic Sleep Wake Cycle Disorders 		0.300 Biomarker disease CTD_human
CUI: C0751758
Disease: Advanced Sleep Phase Syndrome
Advanced Sleep Phase Syndrome 		0.300 Biomarker disease CTD_human
CUI: C0751759
Disease: Non-24 Hour Sleep-Wake Disorder
Non-24 Hour Sleep-Wake Disorder 		0.300 Biomarker disease CTD_human
CUI: C0751760
Disease: Shift-Work Sleep Disorder
Shift-Work Sleep Disorder 		0.300 Biomarker disease CTD_human
CUI: C0877792
Disease: Sleep Disorders, Circadian Rhythm
Sleep Disorders, Circadian Rhythm 		0.300 Biomarker group CTD_human
CUI: C0917801
Disease: Sleeplessness
Sleeplessness 		0.100 Biomarker phenotype HPO
CUI: C3279991
Disease: DELAYED SLEEP PHASE DISORDER, SUSCEPTIBILITY TO
DELAYED SLEEP PHASE DISORDER, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation phenotype CLINVAR
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 AlteredExpression group BEFREE Higher expression of cry1 in the right-sided colon tumor tissue was associated with worse survival in women and the expression of cry1 in the left-sided colorectum was significantly higher in the adjacent tissue compared to tumor in men but not in women. 29940771 2018