CRY2, cryptochrome circadian regulator 2, 1408

N. diseases: 76; N. variants: 9
Disease: Gestational Diabetes ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.030 GeneticVariation phenotype BEFREE The T2D risk SNP rs11605924 in the CRY2 gene was associated with increased GDM risk in Scandinavian but decreased GDM risk in Punjabi Indian women. 30919529 2019
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.030 GeneticVariation phenotype BEFREE Notably, T2D risk alleles of the variant rs1552224 near CENTD2, rs11708067 in ADCY5 and rs11605924 in CRY2 genes associated with protection from GDM regardless of criteria applied (p < 0.025). 30089489 2018
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.030 Biomarker phenotype BEFREE These data document for the first time that the expression of BMAL1, PER3, PPARD and CRY2 genes is altered in GDM compared to normal pregnant women and support the notion that deranged expression of clock genes may play a pathogenic role in GDM. 23323702 2013