CRYAB, crystallin alpha B, 1410

N. diseases: 200; N. variants: 30
Disease: Alzheimer's Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.050 AlteredExpression disease BEFREE Manifestation and progression of AD-like pathology in OXYS rats were accompanied by an increased level of detergent-insoluble p-Ser59-CryaB in the brain cortex, while the CryaB amount did not change. p-Ser59-CryaB was absent in the detergent-soluble protein fraction of the cortex in both rat strains. 30664924 2019
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.050 Biomarker disease BEFREE To test this, we crossed αB-crystallin/HspB2 deficient (CRYAB⁻/⁻HSPB2⁻/⁻) mice with AD model transgenic mice expressing mutant human amyloid precursor protein. 21379584 2011
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.050 Biomarker disease LHGDN An increase in S-glutathionylated proteins in the Alzheimer's disease inferior parietal lobule, a proteomics approach. 17387692 2007
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.050 Biomarker disease LHGDN AlphaB-crystallin, a small heat-shock protein, prevents the amyloid fibril growth of an amyloid beta-peptide and beta2-microglobulin. 16053447 2005
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.050 AlteredExpression disease LHGDN Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model. 12600716 2003