Further studies found that the high CRYAB and p53 co-expression was also significantly correlated with pathological grade (<i>P</i>=0.024), lymph node metastasis (<i>P</i>=0.000), Distant metastasis (<i>P</i>=0.015), TNM stage (<i>P</i>=0.013), and survival (<i>P</i>=0.000).
Kaplan-Meier method and multivariate survival analysis indicated that high expression of CRYAB, MVD, invasion depth, TNM stages, and tumor differentiation, as well as LNM significantly correlate with poor prognosis of GC patients.High expression of CRYAB may contribute to angiogenesis, invasion and metastasis of GC.