PARP1, poly(ADP-ribose) polymerase 1, 142

N. diseases: 565; N. variants: 23
Disease: Malignant transformation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.030 Biomarker phenotype BEFREE PARP-1 regulates metastatic melanoma through modulation of vimentin-induced malignant transformation. 23785295 2013
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.030 AlteredExpression phenotype BEFREE Epigenetic mediated transcriptional activation of PARP-1 participates in silica-associated malignant transformation of human bronchial epithelial cells. 20123007 2010
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.030 AlteredExpression phenotype BEFREE We propose that exposure to asbestos inhibits the PARP1 activity possibly resulting in higher DNA instability, thus causing malignant transformation. 21543585 2011