PARP1, poly(ADP-ribose) polymerase 1, 142

N. diseases: 565; N. variants: 23
Disease: Enzyme inhibition disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0877008
Disease: Enzyme inhibition disorder
Enzyme inhibition disorder 		0.040 AlteredExpression phenotype BEFREE Olaparib activity in CC involved both PARP enzyme inhibition and trapping. 31434613 2019
CUI: C0877008
Disease: Enzyme inhibition disorder
Enzyme inhibition disorder 		0.040 GeneticVariation phenotype BEFREE This complex was thus selected for evaluating stability under physiological conditions and possible interactions with serum albumin, as well in PARP-1 enzyme inhibition assays and preliminary ex vivo toxicity experiments on healthy rat tissues. 29570944 2018
CUI: C0877008
Disease: Enzyme inhibition disorder
Enzyme inhibition disorder 		0.040 Biomarker phenotype BEFREE PARP enzyme inhibition alleviates diabetic nephropathy through decreasing inflammation, oxidative stress, and renal fibrosis. 28224182 2017
CUI: C0877008
Disease: Enzyme inhibition disorder
Enzyme inhibition disorder 		0.040 AlteredExpression phenotype BEFREE Besides, HDACs inhibition activity and PARP-1 enzyme inhibition of SAA1 were also studied. 29031068 2017