It induced G<sub>2</sub>/M phase arrest in HCT116 cells, associated with a marked decrease in cyclin B and CDK1 protein expression and increased caspase activation, PARP cleavage, chromatin condensation, and sub-G<sub>1</sub> apoptosis.
Our findings proved that the upregulation of <i>PARP-1</i> is associated with tumor progression and poor prognosis in Saudi patients with colorectal cancer, suggesting that <i>PARP-1</i> can be novel and valuable signatures for predicting the clinical outcome of patients with colorectal cancer.
In conclusion, this meta-analysis suggests that the PARP-1rs1136410: T > C polymorphism is a susceptibility factor for GI cancers, but the variant allele of MGMT rs12917: C > T polymorphism appears to be a protective factor for colorectal cancer.