PARP1, poly(ADP-ribose) polymerase 1, 142

N. diseases: 565; N. variants: 23
Disease: HER2-negative breast cancer ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4733095
Disease: HER2-negative breast cancer
HER2-negative breast cancer 		0.030 Biomarker disease BEFREE Prospect for Application of PARP Inhibitor in Patients with HER2 Negative Breast Cancer. 31182917 2019
CUI: C4733095
Disease: HER2-negative breast cancer
HER2-negative breast cancer 		0.030 AlteredExpression disease BEFREE Furthermore, these data suggest that the PARPi sensitivity we previously observed in HER2+ breast cancer cells may be due to elevated PARP1 expression. 25833211 2015
CUI: C4733095
Disease: HER2-negative breast cancer
HER2-negative breast cancer 		0.030 Biomarker disease BEFREE Therefore, susceptibility of HER2+ breast cancer cells to PARP inhibition may be because of inhibition of NF-κB signaling driven by HER2. 22987487 2012