Cleft-side MxI2agenesis in CLP subjects appears to be largely a genetically controlled anomaly associated with cleft development, rather than a collateral environmental consequence of the adjacent cleft defect, since increased hypodontia involving multiple missing teeth observed remote from a cleft clearly has a significant genetic basis.
PDC and Mn.I2.C transposition appear to be associated with significantly increased M3 agenesis (P <.01), representing the posterior orofacial field, and Mx.C.P1 transposition appears to be associated with conspicuously elevated MxI2agenesis (P <.001), representing the anterior orofacial field.