|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sputum protein lysates were analysed for p38 activation in a validation study (n = 24 asthma, n = 8 healthy) by western blotting.
|
31808595 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings highlight the importance of p38 MAPK in the pathogenesis of NTHi-induced steroid resistance, and this combined treatment approach may be a novel strategy against steroid-resistant asthma.
|
31445014 |
2019 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Wnt/β-catenin signaling pathway regulates asthma airway remodeling by influencing the expression of c-Myc and cyclin D1 via the p38 MAPK-dependent pathway.
|
31602218 |
2019 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings indicate that RPYD can protect asthma host from OVA-induced airway inflammation and AHR via down-regulation of NF-κB and p38 MAPK activities.
|
30589094 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Blockade of p38 could alleviate airway remodeling which might provide a new therapeutic target for asthma.
|
30428724 |
2018 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Exposure to diisodecyl phthalate exacerbated Th2 and Th17-mediated asthma through aggravating oxidative stress and the activation of p38 MAPK.
|
29448086 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we revealed that OX40L could regulate differentiation of helper T cells via PI3K/AKT and p38 MAPK signaling pathway in asthma.
|
29554934 |
2018 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
At last the immune blot of the protein extracted from lung tissues demonstrated that paeonol decreased the expression of TLR4 and the nuclear translocation of NF-<i>κ</i>B, as well as the phosphorylation levels of P38 and ERK in asthma model.
|
30186353 |
2018 |
|
Asthma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
GLCCI1 deficiency in asthmatic mice inhibits the activation of GR and MKP-1 and leads to more obvious phosphorylation of p38 MAPK, leading to a decremental sensitivity to GCs.
|
30511684 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Peptide *CRRETAWAC* antagonizes fibronectin-induced cytokine synthesis and secretion of airway smooth muscle cells via the inhibition of FAK and p38 MAPK, and is a potential agent for the therapy of asthma.
|
28402030 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both p38 MAPK and oxidative stress were found to play a critical role in this process and simultaneous inhibition of these two pathways significantly reduced the O<sub>3</sub>-elicited detrimental effects on the asthma exacerbation.
|
29284473 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Flow cytometry analysis identified significantly stronger p38 phosphorylation in CD14+ monocytes from steroid resistant than steroid sensitive asthmatics (p = 0.014), whereas no difference was found in phosphorylation of ERK or JNK in CD14+ cells from these two groups of asthmatics.
|
26517722 |
2015 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TNF-α-induced phosphorylated p38 mitogen-activated protein kinase levels were increased in ASMCs from patients with severe asthma compared with those from patients with nonsevere asthma and nonasthmatic subjects, whereas TNF-α-induced phosphorylated c-Jun N-terminal kinase and phosphorylated extracellular signal-related kinase levels were increased in all asthmatic groups.
|
22947346 |
2012 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that the overall effect of p38 MAPK inhibition would be beneficial in inflammatory diseases such as rheumatoid arthritis and asthma.
|
12641490 |
2003 |