|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Correction to: inhibition of p38 MAPK activity leads to cell type-specific effects on the molecular circadian clock and time-dependent reduction of glioma cell invasiveness.
|
30674294 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the long run, CM544 leads to the dephosphorylation of p38 and to a massive cleavage of PARP-1, confirming the block of C6 rat glioma cell proliferation in the G1/S checkpoint and the occurrence of necrotic cell death.
|
30678338 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we test if timed application of the specific p38 MAPK inhibitor VX-745 reduces glioma cell invasive properties in vitro.
|
29316898 |
2018 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, RUNX1 may be one of the putative molecular targeted therapies against glioma metastasis and angiogenesis through the activation of p38 MAPK signaling pathway.
|
28012022 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
And p38 chemical inhibitor (SB203580) could block these effects in glioma treated with TMZ, suggesting a direct up-regulation of the p38 signaling pathway.
|
28569417 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore it appears that GADD45β might play a role in glioma stem cell survival and that p38 MAP kinase may not be directly activated by GADD45β.
|
27658347 |
2016 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Glioma CM stimulated p38 mitogen-activated protein kinase (MAPK) phosphorylation, and a p38 MAPK inhibitor, SB203580, suppressed CM-induced NO production in BV2 cells.
|
27609291 |
2016 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Knockdown of miR-155 enhanced the anticancer effect of TMZ on glioma by targeting the MAPK13 and MAPK14-mediated oxidative stress and apoptosis, but did not affect the secretion of MMP2 and MMP9.
|
25535908 |
2015 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Deletion of the SPARC acidic domain or EGF-like module reduces SPARC-induced migration and signaling through p38 MAPK/HSP27 in glioma.
|
22114076 |
2012 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We identify mitogen-activated protein kinase (MAPK) kinase 3 (MKK3) as a key activator of p38 MAPK in glioma; MKK3 activation is strongly correlated with p38 activation in vitro and in vivo.
|
17406030 |
2007 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Finally, p38 but not extracellular signal-regulated protein kinase activation was required for TRPV1-mediated CPS-induced apoptosis of glioma cells.
|
17442041 |
2007 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas.
|
17616668 |
2007 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Glial cell-derived neurotrophic factor (GDNF) promotes low-grade Hs683 glioma cell migration through JNK, ERK-1/2 and p38 MAPK signaling pathways.
|
16814421 |
2006 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Constitutive phosphorylation of p38 MAPK and JNK was observed in these glioma cells.
|
16964394 |
2006 |