CSF2, colony stimulating factor 2, 1437

N. diseases: 1028; N. variants: 7
Disease: Craniosynostosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010278
Disease: Craniosynostosis
Craniosynostosis 		0.020 Biomarker disease BEFREE In a patient acute lymphoblastic leukemia xenograft model of CRS and neuroinflammation (NI), GM-CSF neutralization resulted in a reduction of myeloid and T cell infiltration in the central nervous system and a significant reduction in NI and prevention of CRS. 30463995 2019
CUI: C0010278
Disease: Craniosynostosis
Craniosynostosis 		0.020 Biomarker disease BEFREE Of note, we also found that the genetic inactivation of GMCSF does not impair the antitumor function or proliferative capacity of CAR T-cells <i>in vitro</i> We conclude that it is possible to prevent CRS by using "all-in-one" GMCSF-knockout CAR T-cells. 30804212 2019