|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
mAbs: Monoclonal antibodies; EF2: elongation factor 2; ITs: Immunotoxins; DT: Diphtheria toxin; PE: Pseudomonas exotoxin; dgA: de-glycosylated A-chain of ricin; rGel: recombinant de-glycosylated form of gelonin; NKC: natural killer cells; HTR: human transferrin receptor; EGF: epidermal growth factor; GM-CSF: granulocyte-macrophage colony-stimulating factor; DAB389: truncated Diphtheria toxin; B-CCL: B-cell chronic lymphocytic leukemia; RCC: renal cell carcinoma; GVHD: Graft-versus-host disease; EGFR: epidermal growth factor receptor; AML: acute myeloid leukemia; Fab: fragment antigen-binding; dsFv: disulfide-stabilized fragment variable; scFv: single-chain fragment variable; B-ALL: B-lineage Acute Lymphoblastic Leukemia; Fv: fragment variable; HCL: hairy cell leukemia; IL-2R: Interleukin-2 receptor; CR: complete response; CLL: chronic lymphocytic leukemia; ATL: adult T-cell leukemia; DARPins: designed Ankyrin repeat proteins; pmol: picomolar; HAMA: human-anti mouse antibody.
|
28282218 |
2017 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Addition of cytosine arabinoside (Ara-C) to truncated diphtheria toxin (DT388) fused to granulocyte macrophage-colony stimulating factor (GMCSF) or interleukin-3 (IL3) was studied in a NOD/SCID mouse model of human AML.
|
15380349 |
2004 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeted therapies include targeted antibody therapy; inhibitors of FLT3, KIT, and farnesyltransferase; diphtheria toxin conjugated to the granulocyte-macrophage colony-stimulating factor; and antisense oligonucleotides.
|
12483109 |
2003 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
We tested the safety and efficacy of a diphtheria fusion protein [diphtheria toxin (DT)388 granulocyte-macrophage colony-stimulating factor (GMCSF)] directed against the GMCSF receptor that is strongly expressed by leukemic blasts.
|
12006512 |
2002 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The fusion toxin consists of a truncated diphtheria toxin (DT) linked to human granulocyte-macrophage colony stimulating factor (GM).
|
11465948 |
2001 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Variable cytotoxicity of diphtheria toxin 388-granulocyte-macrophage colony-stimulating factor fusion protein for acute myelogenous leukemia stem cells.
|
11146161 |
2000 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
A genetically engineered fusion toxin targeted to acute myeloid leukemic (AML) blasts was designed with the first 388 amino acid residues of diphtheria toxin with an H-M linker fused to human granulocyte-macrophage colony-stimulating factor.
|
10336877 |
1999 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The fusion toxin DTctGMCSF has been constructed by genetically replacing the native receptor-binding domain of diphtheria toxin (DT) with human granulocyte-macrophage colony stimulating factor (GMCSF).
|
9675065 |
1998 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor is toxic to blasts from patients with juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia.
|
9834234 |
1998 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Malignant progenitors from patients with acute myelogenous leukemia are sensitive to a diphtheria toxin-granulocyte-macrophage colony-stimulating factor fusion protein.
|
9657759 |
1998 |
|
Diphtheria
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
DTctGMCSF was specifically immunoreactive with antidiphtheria toxin and anti-GMCSF antiseras, and exhibited the characteristic catalytic activity of diphtheria toxin, catalyzing the in vitro ADP-ribosylation of purified elongation factor 2.
|
9168436 |
1997 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor eliminates acute myeloid leukemia cells with the potential to initiate leukemia in immunodeficient mice, but spares normal hemopoietic stem cells.
|
9345060 |
1997 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Modulation of the apoptotic response of human myeloid leukemia cells to a diphtheria toxin granulocyte-macrophage colony-stimulating factor fusion protein.
|
9345050 |
1997 |
|
Diphtheria
|
0.100 |
Biomarker
|
disease |
BEFREE |
To target the lethal action of diphtheria toxin (DT) to high affinity granulocyte-macrophage colony-stimulating factor (GMCSF) receptors on AML blasts, we have produced a recombinant chimeric fusion toxin, DTctGMCSF.
|
9168435 |
1997 |