CSF2, colony stimulating factor 2, 1437

N. diseases: 1028; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Cases of spontaneous CSF leak associated with pituitary tumor apoplexy are uncommon in the literature with pneumocephalus or pneumosella being rare, especially spontaneous occurrence of pneumocephalus being extremely rare. 31376705 2020
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Risk of neurological deterioration (1.6-point increase in National Institutes of Health Stroke Scale at 24 hours) and poor outcome (adjusted odds ratio, 1.34 [95% CI, 1.15-1.56]) was also greater for every 10% increase in ΔCSF. 31818229 2020
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Morphometric (callosal angle, ventricular surface, third ventricular width, and Evans' index) and velocimetric parameters (stroke volume of the aqueductal (SVa) CSF) parameters were measured prior and after surgery with brain MRI. 31069530 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE We found that CSF entered the aged brain along perivascular tracts; this process was reduced by experimental stroke and was rescued by TGF-β receptor inhibition. 31721012 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE The median aqueductal CSF stroke volume was significantly larger in patients compared with healthy controls (103.5 μL; interquartile range, 69.8-142.8 μL) compared with 62.5 μL (interquartile range, 58.3-73.8 μL; <i>P</i> < .01) and was significantly reduced 3 months after shunt surgery from 94.8 μL (interquartile range, 81-241 μL) to 88 μL (interquartile range, 51.8-173.3 μL; <i>P</i> < .05). 30792248 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE We also show that TLR4 activation, very likely mediated by ligands such as HMGB1 released to CSF after stroke, is necessary to keep an increased proliferation of NSCs as well as to promote differentiation from type C cells into neuroblasts promoting their migration. 31059808 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE We hypothesized that IL-6 released into CSF after stroke by wt-tPA through activation of NMDA-Rs and upregulation of ET-1 and JNK contribute to impairment of cerebrovascular autoregulation and increased histopathology. 29476447 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Conclusion The diagnosis of HaNDL is based on clinical and CSF criteria, but neuroimaging, including CT perfusion, can be helpful in differentiating the clinical syndrome from stroke. 28971700 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Granulocyte-macrophage colony stimulating factor (GM-CSF) has neuroprotective properties in experimental stroke and been demonstrated to reverse immunodepression in sepsis patients. 29576323 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 GeneticVariation group BEFREE Complications included post-operative CSF leak (23.8%), stroke (19%), and meningitis (14.3%). 29582975 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Spinal contribution to CSC significantly positively correlated with CSF stroke volume. 30428887 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE PC-MRI in axial plane with velocity encoding of 5 cm/sec was used to quantitatively assess CSF flow through the cerebral aqueduct to determine the aqueductal stroke volume, which was then correlated to cyst size using Pearson's correlation. 29480683 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 GeneticVariation group BEFREE Mann-Whitney comparisons showed the percentage change in CSF stroke volume (resting to postcoughing) to be significantly different between patient groups (<i>P</i> = .04). 29748208 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Both CSF stroke volume and flow rate overlapped between lumbar puncture/lumbar drainage responders and nonresponders. 30467214 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 GeneticVariation group BEFREE Three categories of CSF flow parameters were measured: peak velocity (V<sub>peak</sub> ), stroke volume (SV), and minute flow volume (MinV) covering the whole cycle; peak velocity (V<sub>peak-s</sub> , V<sub>peak-d</sub> ) and flow volume (Vol<sub>s</sub> , Vol<sub>d</sub> ) of the systole and diastole, respectively; net flow. 28247411 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 GeneticVariation group BEFREE Three studies on stroke reported mixed findings but were limited due to the small number of patients undergoing CSF examination, whilst neurosyphilis continued to be reported as a common cause of dementia in studies from North Africa. 28859081 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE AD, Alzheimer's disease; FAST, Functional Assessment Staging; 2D-DIGE, two-dimensional differential gel electrophoresis; MALDI-TOF/TOF/MS, matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry; CSF, cerebrospinal fluid; Aβ, amyloid beta; MMSE, Mini Mental State Examination; MRI, magnetic resonance imaging; NINCDS-ADRDA, National Institute for Neurological Diseases and Stroke/Alzheimer's Disease and Related Disorders Association; CHAPS, 3-((3-cholamidopropyl) dimethylammonio)-1-propanesulfonate; DTT, dithiothreitol; SDS-PAGE, SDS-polyacrylamide gel electrophoresis; DIA, differential in-gel analysis; BVA, biological variation analysis; CBB, Coomassie brilliant blue; 2DE, two-dimensional gel electrophoresis; TFA, trifluoroacetic acid; ACTH, adrenocorticotropic hormone; Apo A-1, apolipoprotein A-1; AHSG, alpha-2-HS-glycoprotein; Apo A-4, apolipoprotein A-4; MCI, mild cognitive impairment. 28107809 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Further investigations are necessary to better understand the role of GM-CSF on neural regeneration during the recovery phase of a stroke, as well as the intracellular signal transduction pathways that mediate neuroprotection. 19361262 2009