CSF2, colony stimulating factor 2, 1437

N. diseases: 1028; N. variants: 7
Disease: Meningeal Carcinomatosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0220654
Disease: Meningeal Carcinomatosis
Meningeal Carcinomatosis 		0.020 Biomarker disease BEFREE Methotrexate, given systemically at high doses (3.5-8 gm/m<sup>2</sup>), achieves cytotoxic concentrations in the CSF and has been shown to prolong survival in patients with LC. 31175053 2019
CUI: C0220654
Disease: Meningeal Carcinomatosis
Meningeal Carcinomatosis 		0.020 Biomarker disease BEFREE In univariate analysis, a Karnofsky performance scale index (KPI) ≥70% (<i>P</i>=0.001), age ≤55 years at LC diagnosis (<i>P</i>=0.022), cerebrospinal fluid (CSF) protein <100 mg/dL (<i>P</i>=0.018) and no more than mild or moderate neurologic deficits (NFS ≤2; <i>P</i>=0.007) were predictive of longer OS. 30697071 2019