|
Leukocytosis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In this paper, we provide evidence supporting an untapped clinical paradigm linking G-CSF secretion to the induction of leukocytosis and expansion of myeloid-derived suppressor cells, providing an explanation for the association between leukocytosis, elevated neutrophil-to-lymphocyte ratios and prognosis in non-small cell lung cancer.
|
31080780 |
2019 |
|
Leukocytosis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In vitro and in vivo experiments revealed that tumor-derived G-CSF and G-CSF-mediated IL-6 production from the tumor microenvironment are involved in the development of leukocytosis and thrombocytosis in patients with endometrial cancer.
|
31741758 |
2019 |
|
Leukocytosis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Commonly reported side effects of G-CSF include deep throbbing bone pain, severe myalgia and leucocytosis.
|
31203715 |
2019 |
|
Leukocytosis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The liver metastasis was accompanied by progressive leukocytosis and elevated serum G-CSF and demonstrated rapid tumor growth during a six-month period, whereas the non-G-CSF-producing pulmonary metastasis grew slowly during the same period.
|
29725401 |
2018 |
|
Leukocytosis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Laboratory data showed leukocytosis (leukocyte count 113.3 × 10<sup>3</sup> /µL) and high serum G-CSF levels (441 pg/mL; normal range: <39.0 pg/mL).
|
28185423 |
2017 |
|
Leukocytosis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
An advanced granulocyte-colony stimulating factor (G-CSF)-producing tumor is rare, and it exhibits leukocytosis in association with high serum G-CSF levels.
|
28789371 |
2017 |
|
Leukocytosis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The patient's laboratory tests showed marked leukocytosis, elevated levels of C-reactive protein and multiple cytokines, including interleukin-6 (IL-6) and granulocyte colony-stimulating factor (G-CSF).
|
23058034 |
2012 |
|
Leukocytosis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Administration of G-CSF is accompanied by significant increase of circulating neutrophils 2 days post-ischemia but leukocytosis is restricted to the vessel compartment and has no deleterious effect on lesion formation and functional recovery.
|
20026112 |
2010 |
|
Leukocytosis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
However, G-CSF causes marked leukocytosis that potentially induces adverse cardiovascular events.
|
16224058 |
2005 |
|
Leukocytosis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The transplanted nude mice also showed leukocytosis with a high serum G-CSF level.
|
12079515 |
2002 |
|
Leukocytosis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
At initial presentation, the patient had hepatosplenomegaly, leukocytosis (29100 x 10(6)/l) with an increase of mature neutrophils (83%), 20q- chromosomal abnormality, an increased leukocyte alkaline phosphatase score, elevated serum levels of vitamin B12 and uric acid, a low serum level of granulocyte colony-stimulating factor, and high serum IgM (1015 mg/dl: lambda type M protein).
|
9713172 |
1998 |
|
Leukocytosis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In a patient with invasive bladder carcinoma, we found that the tumor cells produced G-CSF responsible for a remarkable leucocytosis.
|
7514696 |
1994 |
|
Leukocytosis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results suggested that the production of G-CSF is a common event in human tumour xenografts associated with leukocytosis, but that factors other than G-CSF are also likely to be involved.
|
7691144 |
1993 |
|
Leukocytosis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results indicated that the autonomous production of granulocyte colony-stimulating factor in this bladder carcinoma induced paraneoplastic leukocytosis.
|
7681120 |
1993 |