|
Bowen's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings support that p16 positivity limited to clonal nests in CSK is normal. p16 positivity in clonal nests of CSK in isolation without concurrent atypical histologic features should not be used to support a diagnosis of BD.
|
30828837 |
2019 |
|
Seborrheic keratosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
While p16 is often reported as positive in BD and negative in SK, p16 expression in CSK is rarely studied.
|
30828837 |
2019 |
|
Lens Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The effects of c-Src kinase on EMT signaling pathway in human lens epithelial cells associated with lens diseases.
|
31703690 |
2019 |
|
Perianal Squamous Intraepithelial Neoplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings support that p16 positivity limited to clonal nests in CSK is normal. p16 positivity in clonal nests of CSK in isolation without concurrent atypical histologic features should not be used to support a diagnosis of BD.
|
30828837 |
2019 |
|
Obesity
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among the six SNPs, three were associated with obesity risk (CSK rs1378942: odds ratio (OR) = 1.20, 95% confidence interval (CI) 1.01-1.43, P = 0.042; MTHFR rs1801133: OR = 1.19, 95% CI 1.05-1.34, P = 0.006; FGF5 rs16998073: OR = 1.14, 95% CI 1.00-1.29, P = 0.047).
|
30217759 |
2018 |
|
Virus Diseases
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
Here, we demonstrated that TRIM25 interacted with c-Src and underwent tyrosine phosphorylation by c-Src kinase upon viral infection and the phosphorylation is required for the complete activation of RIG-I signaling.
|
30100205 |
2018 |
|
Renal fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recent studies have reported that high glucose (HG) conditions may contribute to the acceleration of renal cell apoptosis and renal fibrosis by inducing epithelial-mesenchymal transition (EMT) of tubular epithelial cells, in which c-Src kinase and transforming growth factor (TGF)-β are key modulators.
|
30116401 |
2018 |
|
Sarcoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
HBc-mediated sarcoma (Src) kinase activation was associated with down-regulation of C-terminal Src kinase (Csk).
|
29401603 |
2018 |
|
Malignant neoplasm of soft tissue
|
0.010 |
AlteredExpression
|
group |
BEFREE |
HBc-mediated sarcoma (Src) kinase activation was associated with down-regulation of C-terminal Src kinase (Csk).
|
29401603 |
2018 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
The molecular mechanisms leading to ET-1 upregulation in diabetes are not entirely defined. c-Src tyrosine kinase regulates important pathophysiological aspects of vascular response to insults.
|
27102411 |
2016 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
The molecular mechanisms leading to ET-1 upregulation in diabetes are not entirely defined. c-Src tyrosine kinase regulates important pathophysiological aspects of vascular response to insults.
|
27102411 |
2016 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
This isoform competes with the wild-type LYP for binding to CSK and results in hyporesponsiveness of CD4(+) T cells to antigen stimulation in T1D subjects.
|
26631741 |
2016 |
|
Endometriosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the endometriotic lesions, prostaglandin E2 (PGE2) produced by cyclooxygenase-2 (COX-2), binds to its EP4 receptor (EP4), and via c-Src kinase induces MMPs activation, promoting endometriosis.
|
27038655 |
2016 |
|
ovarian neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Low CSK methylation and high CSK expression were both significantly associated (p < 0.05) with improved progression-free survival and overall survival in HGSOC patients.
|
27765068 |
2016 |
|
Malignant neoplasm of ovary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Low CSK methylation and high CSK expression were both significantly associated (p < 0.05) with improved progression-free survival and overall survival in HGSOC patients.
|
27765068 |
2016 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Low CSK methylation and high CSK expression were both significantly associated (p < 0.05) with improved progression-free survival and overall survival in HGSOC patients.
|
27765068 |
2016 |
|
Henoch-Schoenlein Purpura
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results do not support association between PTPN22/CSK and HSP.
|
26458874 |
2015 |
|
Vasculitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Role of PTPN22 and CSK gene polymorphisms as predictors of susceptibility and clinical heterogeneity in patients with Henoch-Schönlein purpura (IgA vasculitis).
|
26458874 |
2015 |
|
Hormone refractory prostate cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results identify CSK downregulation as a principal driver of SRC activation and castration resistance and validate SRC as a drug target in a molecularly defined subclass of CRPCs.
|
26091350 |
2015 |
|
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Paradoxically, the protein levels of Csk were elevated in some human carcinomas.
|
24648518 |
2014 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, we show that cleaved fragments of eEF2 can induce nuclear morphological changes and aneuploidy similar to those in cancer cells, suggesting that there is an additional mechanism for Csk in tumorigenesis through regulation of eEF2 subcellular localization.
|
24648518 |
2014 |
|
synovial sarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry of phosphorylated SRC and its regulators CSK and PTP1B (PTPN1) was conducted in 30 synovial sarcomas.
|
23580575 |
2013 |
|
Giant Cell Arteritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To analyse the role of the PTPN22 and CSK genes, previously associated with autoimmunity, in the predisposition and clinical phenotypes of giant cell arteritis (GCA).
|
23946333 |
2013 |
|
15q24 Microdeletion
|
0.010 |
Biomarker
|
disease |
BEFREE |
There are several candidate genes within the SRO, including CYP11A1, SEMA7A, CPLX3, ARID3B, STRA6, SIN3A and CSK, that may predispose to many of the clinical features observed in individuals with 15q24 deletion syndrome.
|
22216833 |
2012 |
|
Patent ductus arteriosus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In contrast, deletion of CSK alone fails to induce neoplasia, while oncogenic Kras expression yields PDA at low frequency after a latency of 12 months.
|
21242978 |
2011 |