CSK, C-terminal Src kinase, 1445

N. diseases: 91; N. variants: 8
Disease: Autoimmune Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.050 Biomarker group BEFREE Furthermore, PTPN22 binds to C-Src tyrosine kinase (CSK) forming a key complex in autoimmunity. 28874816 2017
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.050 GeneticVariation group BEFREE Two well-known CSK (CSK rs34933034 and CSK rs1378942) and two functional PTPN22 (PTPN22 rs2476601 (rs2476601" genes_norm="26191">R620W) and PTPN22 rs33996649 (rs33996649" genes_norm="26191">R263Q)) polymorphisms, previously associated with autoimmunity, were genotyped with TaqMan single nucleotide polymorphism (SNP) genotyping assays. 26458874 2015
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.050 GeneticVariation group BEFREE In this respect, the finding that genetic variation in CSK and PTPN22 is strongly associated with multiple autoimmune diseases is of interest. 24333531 2014
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.050 GeneticVariation group BEFREE To analyse the role of the PTPN22 and CSK genes, previously associated with autoimmunity, in the predisposition and clinical phenotypes of giant cell arteritis (GCA). 23946333 2013
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.050 GeneticVariation group BEFREE The autoimmunity risk variant LYP-W620 cooperates with CSK in the regulation of TCR signaling. 23359562 2013