|
Hypertensive disease
|
0.090 |
GeneticVariation
|
group |
BEFREE |
C-src tyrosine kinase gene rs1378942 polymorphism and hypertension in Asians: Review and meta-analysis.
|
30291896 |
2018 |
|
Hypertensive disease
|
0.090 |
GeneticVariation
|
group |
BEFREE |
The present study results indicated that the mutant alleles of CSK rs1378942 and CSK-MIR4513 rs3784789 had the strongest protective effects against hypertension in the middle group of 24 h estimated urinary sodium-potassium excretion ratio.
|
28273873 |
2017 |
|
Hypertensive disease
|
0.090 |
GeneticVariation
|
group |
BEFREE |
The results suggested that both CYP17A1 rs11191548 and FGF5 rs16998073 polymorphisms were significantly associated with hypertension risk in East Asians (CYP17A1 rs11191548 (random effect model): OR=1.16, 95% CI 1.07-1.25, p=3.59×10(-4), I(2)=78.2%, p (heterogeneity)=1.14×10(-4); FGF5 rs16998073 (random effect model): OR=1.30, 95% CI 1.23-1.37, p=6.29×10(-21), I(2)=65.0%, p (heterogeneity)=0.009); whereas no significant association was observed for CSK rs1378942 (fix effect model: OR=1.09, 95% CI 0.98-1.22, p=0.128, I(2)=0.0%, p (heterogeneity)=0.820), or MTHFR rs17367504 (fix effect model: OR=1.06, 95% CI 0.98-1.14, p=0.126, I(2)=0.0%, p (heterogeneity)=0.822).
|
22959498 |
2013 |
|
Hypertensive disease
|
0.090 |
GeneticVariation
|
group |
BEFREE |
We also observed a significant association of 4 SNPs and the GRS with hypertension (ATP2B1 rs17249754: P = 0.02; CSK rs1378942: P = 0.02; CYP17A1 rs1004467: P = 0.02; MTHFR rs1801133: P = 0.03; GRS: P = 0.0004).
|
23591986 |
2013 |
|
Hypertensive disease
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms on the COMT, ATP2B1, CYP11A1 and the CSK genes were confirmed to be associated with hypertension and blood pressure (BP).
|
21633377 |
2012 |
|
Hypertensive disease
|
0.090 |
Biomarker
|
group |
BEFREE |
Significant associations were replicated for 7 loci-CASZ1, MTHFR, ITGA9, FGF5, CYP17A1-CNNM2, ATP2B1, and CSK-ULK3-with any or all of these 3 traits: systolic blood pressure (P=1.4x10(-14) to 0.05), diastolic blood pressure (P=1.9x10(-12) to 0.05), and hypertension (P=2.0x10(-14) to 0.006; odds ratio, 1.10 to 1.29).
|
20479155 |
2010 |
|
Hypertensive disease
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Genetic variations in ATP2B1, CSK, ARSG and CSMD1 loci are related to blood pressure and/or hypertension in two Korean cohorts.
|
19960030 |
2010 |
|
Hypertensive disease
|
0.090 |
GeneticVariation
|
group |
BEFREE |
In summary, this study confirmed common genetic variation in ATP2B1, as well as FGF5, CYP17A1, and CSK, to be associated with blood pressure levels and risk of hypertension.
|
20921432 |
2010 |
|
Hypertensive disease
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Four loci-ATP2B1 (ATPase, Ca(++) transporting, plasma membrane 1), CSK (c-src tyrosine kinase), CYP17A1 (cytochrome P450 17A1) and PLEKHA7 (pleckstrin homology domain-containing family A member 7)-were associated with blood pressure and hypertension in the Korean population.
|
20414254 |
2010 |