|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
In this study, we found that LINC00052 was upregulated in HNSCC tumors.
|
31639333 |
2019 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
LINC00052 functions as a tumor suppressor through negatively modulating miR-330-3p in pancreatic cancer.
|
30712321 |
2019 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Some studies on the biological function of long intergenic non-protein-coding RNA 52 (LINC00052) in cancer indicate that this gene can act as either oncogene or tumor suppressor in some kinds of cancers, such as breast cancer, gastric cancer, liver cancer, and lung cancer.
|
31104316 |
2019 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
LINC00052 might be a novel tumor suppressor in cervical cancer.
|
31210293 |
2019 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
In our previous study, we found that LINC00052 was acted as a tumor suppressor in HCC.
|
30098428 |
2018 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Importantly, neutralization of HER3 signaling with HER3 targeting monoclonal antibodies blocked LINC00052 mediated cancer cell proliferation in vitro and tumor growth in vivo, suggesting LINC00052 promoting cancer growth through HER3 signaling.
|
28036286 |
2017 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
In this study, we found that overexpression of LINC00052 could upregulate the EPB41L3 expression and it might serve as a tumor suppressor gene in HCC.
|
28969024 |
2017 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
We also investigated the effects of LINC00052 on tumor prognosis and progression and found that LINC00052 indicated poor prognosis and tumor progression.
|
28337962 |
2017 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Gain and loss of function studies revealed that LINC00052 promoted HNSCC cell proliferation, migration and invasion.
|
31639333 |
2019 |
|
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, cell proliferation, migration and invasion were inhibited through overexpression of LINC00052 in vitro.
|
31210293 |
2019 |
|
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
For another, AsPC-1 and SW1990 cell migration and invasion capacity were also obviously repressed by LINC00052 upregulation.
|
30712321 |
2019 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Long noncoding RNA LINC00052 suppressed the proliferation, migration and invasion of glioma cells by upregulating KLF6.
|
31210314 |
2019 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
LINC00052 upregulates EPB41L3 to inhibit migration and invasion of hepatocellular carcinoma by binding miR-452-5p.
|
28969024 |
2017 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
By using gene trap methods which could knockdown gene expression to find important genes, we found one LncRNA which called intergenic non-protein coding RNA 52 (LINC00052) has the ability to inhibit invasion and migration of hepatocarcinoma cells.
|
27351280 |
2016 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
LINC00052 could repress metastasis and invasion of cervical cancer cell via suppressing STAT3.
|
31210293 |
2019 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
And LINC00052 could suppress CRC cells metastasis both in vivo and in vitro.
|
31104316 |
2019 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Besides, miR-101-3p was involved in LINC00052 inhibits HCC cells proliferation and metastasis.
|
30098428 |
2018 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, XAV939 (inhibitor of β-catenin) was used to treat MGC-803 cells, and we found that LINC00052 promoted proliferation and metastasis, possibly by activation of the Wnt/β-catenin pathway.
|
28337962 |
2017 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Linc00052 knock-down experiments suggest that it could be a key regulator of cholesterol pathways in breast cancer.
|
31301772 |
2019 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
Some studies on the biological function of long intergenic non-protein-coding RNA 52 (LINC00052) in cancer indicate that this gene can act as either oncogene or tumor suppressor in some kinds of cancers, such as breast cancer, gastric cancer, liver cancer, and lung cancer.
|
31104316 |
2019 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Linc00052 knock-down experiments suggest that it could be a key regulator of cholesterol pathways in breast cancer.
|
31301772 |
2019 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Some studies on the biological function of long intergenic non-protein-coding RNA 52 (LINC00052) in cancer indicate that this gene can act as either oncogene or tumor suppressor in some kinds of cancers, such as breast cancer, gastric cancer, liver cancer, and lung cancer.
|
31104316 |
2019 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
And we found a positive relationship between LINC00052 and miR-101-3p, and a negative relationship between miR-101-3p and SOX9 in HCC tissues.
|
30098428 |
2018 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
HER3 and LINC00052 interplay promotes tumor growth in breast cancer.
|
28036286 |
2017 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
HER3 and LINC00052 interplay promotes tumor growth in breast cancer.
|
28036286 |
2017 |