|
Hereditary Cerebral Amyloid Angiopathy, Icelandic Type
|
0.770 |
GeneticVariation
|
disease |
BEFREE |
Instability of the amyloidogenic cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type.
|
9565605 |
1998 |
|
Hereditary Cerebral Amyloid Angiopathy, Icelandic Type
|
0.770 |
Biomarker
|
disease |
BEFREE |
The protein, a mutant of the cysteine protease inhibitor cystatin C, is the amyloid precursor protein in Hereditary Cerebral Hemorrhage with Amyloidosis--Icelandic type (HCHWA-I).
|
10524281 |
1999 |
|
Hereditary Cerebral Amyloid Angiopathy, Icelandic Type
|
0.770 |
Biomarker
|
disease |
BEFREE |
Cystatin-C is an amyloidogenic protein causing hereditary cerebral haemorrhage with amyloidosis-Icelandic type (HCHWA-I).
|
8361651 |
1993 |
|
Hereditary Cerebral Amyloid Angiopathy, Icelandic Type
|
0.770 |
GeneticVariation
|
disease |
BEFREE |
Distinct properties of wild-type and the amyloidogenic human cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type.
|
11299325 |
2001 |
|
Hereditary Cerebral Amyloid Angiopathy, Icelandic Type
|
0.770 |
GeneticVariation
|
disease |
BEFREE |
Proinflammatory response induced by the ex vivo mutant cystatin C protein aggregates suggests that vascular inflammation plays an important role in hereditary cerebral hemorrhage with amyloidosis-Icelandic type.
|
23273574 |
2013 |
|
Hereditary Cerebral Amyloid Angiopathy, Icelandic Type
|
0.770 |
GeneticVariation
|
disease |
BEFREE |
A variant of the cysteine protease inhibitor, cystatin C, forms amyloid deposited in the cerebral vasculature of patients with hereditary cerebral hemorrhage with amyloidosis, Icelandic type (HCHWA-I), leading to cerebral hemorrhages early in life.
|
16612983 |
2006 |
|
Hereditary Cerebral Amyloid Angiopathy, Icelandic Type
|
0.770 |
Biomarker
|
disease |
BEFREE |
To evaluate possible cytotoxicity in this condition solubilized cystatin C amyloid extracted from HCHWA-I leptomeninges was applied to cerebral smooth muscle cells in culture and was found to kill the cells.
|
17963746 |
2007 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
A variant of cystatin C lacking the first NH2-terminal residues and having one amino acid substitution at position 68 forms amyloid deposits mainly in the walls of brain arteries, causing fatal strokes in Icelandic patients with familial cerebral hemorrhage secondary to a form of an autosomal dominant amyloidosis.
|
2541223 |
1989 |
|
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Moreover, HBO-induced endogenous CysC elevation preserved lysosomal membrane integrity after stroke in wild-type rats but not in CysC siRNA infusion or CysC<sup>-</sup><sup>/-</sup> rats.
|
27999137 |
2017 |
|
Cerebrovascular accident
|
0.500 |
AlteredExpression
|
group |
BEFREE |
Taken together, these data unveil a new mechanism of the regulation of caveolin-1 expression by cystatin C in the maintenance of BBB integrity after ischemic brain injury and provide new clues for the identification of potential therapeutic strategies for stroke.
|
31603990 |
2019 |
|
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
The role of cystatin C in cerebral amyloid angiopathy and stroke: cell biology and animal models.
|
16612983 |
2006 |
|
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
We have previously reported that Cystatin C (CysC) is a pivotal mediator in the neuroprotection induced by hyperbaric oxygen (HBO) preconditioning; however, the underlying mechanism and how CysC changes after stroke are not clear.
|
30519802 |
2019 |
|
Cerebrovascular accident
|
0.500 |
AlteredExpression
|
group |
BEFREE |
This prospective observational study investigated the correlation between serum CysC levels and post-stroke cognitive dysfunction at 3 months.
|
31719258 |
2020 |
|
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
No associations were observed between CysC and stroke after additional adjustment for confounding variables.
|
30398035 |
2018 |
|
Cerebrovascular accident
|
0.500 |
AlteredExpression
|
group |
BEFREE |
Increased expression levels of CysC were detected in the regenerating brain of mice after stroke.
|
29722001 |
2018 |
|
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Massive deposition of the variant cystatin C in the cerebral vessels of patients with the Icelandic form of hereditary cerebral hemorrhage with amyloidosis is thought to be responsible for the pathological processes leading to stroke.
|
11202179 |
2001 |
|
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
In participants aged 65 to 99 years with incident ischemic strokes from the Cardiovascular Health Study, we evaluated the association of several risk factors (frailty, frailty components, C-reactive protein, interleukin-6, and cystatin C) assessed before stroke with stroke outcomes of survival, cognitive decline (≥5 points on Modified Mini-Mental State Examination), and activities of daily living decline (increase in limitations).
|
28526765 |
2017 |
|
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Up to now, amyloid-beta (A beta), cystatin C, and prion proteins have been known to be deposited as amyloid in the brain, leading to stroke or dementia.
|
8579098 |
1996 |
|
Dementia
|
0.460 |
AlteredExpression
|
disease |
BEFREE |
We conclude that, in Lewy body disease, the CST3 BB genotype and low CSF CysC levels are associated with dementia, possibly through a disturbed elimination of soluble Abeta(42).
|
20157249 |
2010 |
|
Dementia
|
0.460 |
Biomarker
|
disease |
BEFREE |
Three hypotheses were tested: (1) higher levels of high-sensitivity cardiac troponin T, N-terminal of prohormone brain natriuretic peptide, and cystatin C predict risk of death, cardiovascular disease, HF, and dementia; (2) higher levels of cardiovascular disease biomarkers are associated with increased risk of HF and then secondary increased risk of dementia; and (3) risk of dementia is lower among participants with a combination of lower coronary artery calcium, atherosclerosis, and lower high-sensitivity cardiac troponin T (myocardial injury).
|
28735291 |
2017 |
|
Dementia
|
0.460 |
Biomarker
|
disease |
BEFREE |
Cystatin isolated from chicken egg white, called ovocystatin, has been widely used in the medical and pharmaceutical research due to its structural and biological similarities to human cystatin C. The aim of this study was to assess the effect of administering ovocystatin on the development of dementia-specific cognitive deficits in APP/PS1 transgenic mice.
|
30504006 |
2019 |
|
Dementia
|
0.460 |
Biomarker
|
disease |
BEFREE |
Up to now, amyloid-beta (A beta), cystatin C, and prion proteins have been known to be deposited as amyloid in the brain, leading to stroke or dementia.
|
8579098 |
1996 |
|
Dementia
|
0.460 |
Biomarker
|
disease |
BEFREE |
Progressive dementia and leucoencephalopathy as the initial presentation of late onset hereditary cystatin-C amyloidosis. Clinicopathological presentation of two cases.
|
8866434 |
1996 |
|
Dementia
|
0.460 |
Biomarker
|
disease |
BEFREE |
In contrast, cystatin C was shown to be a protective factor against progression to dementia.
|
29357793 |
2018 |
|
Alzheimer's Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The colocalization of cystatin C, an inhibitor of cysteine proteases, with amyloid beta (Abeta) in parenchymal and vascular amyloid deposits in brains of Alzheimer's disease (AD) patients may reflect cystatin C involvement in amyloidogenesis.
|
15212828 |
2004 |