CST3, cystatin C, 1471

N. diseases: 370; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007138
Disease: Carcinoma, Transitional Cell
Carcinoma, Transitional Cell
0.010 Biomarker disease BEFREE The preoperative serum cystatin-C as an independent prognostic factor for survival in upper tract urothelial carcinoma. 30416134 2020
CUI: C0020295
Disease: Hydronephrosis
Hydronephrosis
0.010 AlteredExpression disease BEFREE As the degree of hydronephrosis increased, the expression of neutrophil percentage, CysC, blood urea nitrogen, SCr and serum uric acid also increased. 31801142 2020
CUI: C2145472
Disease: Urothelial Carcinoma
Urothelial Carcinoma
0.010 Biomarker disease BEFREE The preoperative serum cystatin-C as an independent prognostic factor for survival in upper tract urothelial carcinoma. 30416134 2020
CUI: C3714753
Disease: RETINOSCHISIS 1, X-LINKED, JUVENILE
RETINOSCHISIS 1, X-LINKED, JUVENILE
0.010 AlteredExpression disease BEFREE RA+RS signifificantly decreased the diastolic blood pressure, renal vascular resistance index, and parenchymal thickness, increased 24 h urinary volume as well as lowered the levels of urine mALB and serum cystatin ^C, IL-1β and β2-Mg of SHRs (P <0.05 vs. SHRs). 31388973 2020
CUI: C3850141
Disease: Acute-On-Chronic Liver Failure
Acute-On-Chronic Liver Failure
0.010 Biomarker disease BEFREE This study aimed to compare the performance of neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (CysC) in predicting the 90-day mortality in patients with hepatitis B virus (HBV)-associated ACLF (HBV-ACLF). 31113585 2020
CUI: C4524209
Disease: Lumbodynia
Lumbodynia
0.010 Biomarker phenotype BEFREE We found that urodynia or lumbodynia was more prevalent in women with CST4 than in women with CST3, and cervical hypertrophy was more prevalent in women with CST4 than in women with CST2 and CST3. 31841701 2020
CUI: C0003486
Disease: Aortic Aneurysm
Aortic Aneurysm
0.010 Biomarker disease BEFREE More cathepsin L-positive cells were observed in the AA group than in the DM+AA group; conversely, more cystatin C-positive cells were observed in the DM+AA group than in the AA group. 31096818 2019
CUI: C0004096
Disease: Asthma
Asthma
0.010 AlteredExpression disease BEFREE A higher likelihood of asthma remission was associated with a greater decrease in leptin levels, and a higher likelihood of diabetes remission was predicted by a lesser decrease in CC. 29777230 2019
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders
0.010 Biomarker group BEFREE Cystatin isolated from chicken egg white, called ovocystatin, has been widely used in the medical and pharmaceutical research due to its structural and biological similarities to human cystatin C. The aim of this study was to assess the effect of administering ovocystatin on the development of dementia-specific cognitive deficits in APP/PS1 transgenic mice. 30504006 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.010 Biomarker disease BEFREE The present study aimed to describe a new sarcopenia index (SI), serum creatinine (Scr) × cystatin C-based glomerular filtration rate, and investigate its association with short-term complications after curative resection of CRC. 30648340 2019
CUI: C0013363
Disease: Dysautonomia
Dysautonomia
0.010 Biomarker disease BEFREE Therefore, the aim of this study was to investigate the relationship between CysC and cardiovascular autonomic dysfunction in type 2 diabetic patients without renal dysfunction. 31011584 2019
CUI: C0013384
Disease: Dyskinetic syndrome
Dyskinetic syndrome
0.010 Biomarker disease BEFREE Measurement of serum cystatin C: A valuable tool for evaluating dyskinesia in Parkinson's disease. 31054924 2019
CUI: C0017605
Disease: Angle Closure Glaucoma
Angle Closure Glaucoma
0.010 AlteredExpression disease BEFREE We assume that elevated levels of OPN and cystatin C in POAG and PACG along with altered cathepsin levels may contribute to ECM aberration in glaucoma. 30994369 2019
CUI: C0017606
Disease: Primary angle-closure glaucoma
Primary angle-closure glaucoma
0.010 AlteredExpression disease BEFREE We assume that elevated levels of OPN and cystatin C in POAG and PACG along with altered cathepsin levels may contribute to ECM aberration in glaucoma. 30994369 2019
CUI: C0021053
Disease: Immune System Diseases
Immune System Diseases
0.010 Biomarker group BEFREE Our results might open up an avenue for the development of therapeutic agents for the treatment of cystatin C-related immunological diseases. 31513306 2019
CUI: C0027709
Disease: Nephrocalcinosis
Nephrocalcinosis
0.010 Biomarker disease BEFREE Children born EPT had significantly smaller kidneys (EPT (NC+ NC-) vs control (estimated difference, 11.8 (CI - 21.51 to - 2.09 ml), p = 0.018) and lower but normal cystatin C-based glomerular filtration rate compared with control (estimated difference, - 10.11 (CI - 0.69 to - 19.5), p = 0.035). 31338588 2019
CUI: C0027720
Disease: Nephrosis
Nephrosis
0.010 Biomarker disease BEFREE This longitudinal, prospective study analyzed the first-year profile of two serum renal biomarkers: creatinine (sCr) and cystatin C (sCyC); and six urinary renal biomarkers: neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), transforming growth factor beta-1 (TGF-β1), retinol-binding protein (RBP), cystatin C (uCyC), and microalbuminuria (μALB) in a cohort of 37 infants with UTO divided into three subgroups: 14/37 with unilateral hydro(uretero)nephrosis, 13/37 with bilateral hydro(uretero)nephrosis, and 10/37 patients with lower urinary tract obstruction (LUTO), compared with 24 healthy infants matched by gestational age and birth weight. 30694385 2019
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome
0.010 Biomarker group BEFREE This longitudinal, prospective study analyzed the first-year profile of two serum renal biomarkers: creatinine (sCr) and cystatin C (sCyC); and six urinary renal biomarkers: neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), transforming growth factor beta-1 (TGF-β1), retinol-binding protein (RBP), cystatin C (uCyC), and microalbuminuria (μALB) in a cohort of 37 infants with UTO divided into three subgroups: 14/37 with unilateral hydro(uretero)nephrosis, 13/37 with bilateral hydro(uretero)nephrosis, and 10/37 patients with lower urinary tract obstruction (LUTO), compared with 24 healthy infants matched by gestational age and birth weight. 30694385 2019
CUI: C0031117
Disease: Peripheral Neuropathy
Peripheral Neuropathy
0.010 Biomarker group BEFREE Previous studies have proved that cystatin C (CysC) is an important predictor of both peripheral neuropathy and cardiovascular events. 31011584 2019
CUI: C0037315
Disease: Sleep Apnea Syndromes
Sleep Apnea Syndromes
0.010 AlteredExpression disease BEFREE Baseline CRP levels were positively associated with the odds of asthma but not diabetes or sleep apnea; baseline CC levels were positively associated with asthma, diabetes, and sleep apnea; baseline leptin levels were positively associated with asthma and negatively associated with diabetes and sleep apnea; baseline ghrelin levels were negatively associated with diabetes and sleep apnea. 29777230 2019
CUI: C0039730
Disease: Thalassemia
Thalassemia
0.010 Biomarker group BEFREE We identified 91 participants with HbSS or SB0 thalassemia 5-21 years of age enrolled in a longitudinal sickle cell nephropathy cohort study who had a cystatin C measured during early childhood (4-10 years of age). 30592084 2019
CUI: C0085096
Disease: Peripheral Vascular Diseases
Peripheral Vascular Diseases
0.010 Biomarker group BEFREE Clinical significance First prospective longitudinal cohort study evaluating Cystatin C, copeptin, N-terminal pro-B-type natriuretic peptide (N-BNP), midregional proatrial natriuretic peptide (MR-proANP), and mid-regional proadrenomedullin (MR-proADM) as predictors for peripheral arterial disease (PAD). 31215249 2019
CUI: C0151517
Disease: Complete atrioventricular block
Complete atrioventricular block
0.010 Biomarker disease BEFREE INR, creatinine, NAG, and CysC are proper biomarkers for screening renal dysfunction in Chinese patients with CHB or compensated LC. 30830657 2019
CUI: C0152021
Disease: Congenital heart disease
Congenital heart disease
0.010 Biomarker group BEFREE Creatinine versus cystatin C to estimate glomerular filtration rate in adults with congenital heart disease: Results of the Boston Adult Congenital Heart Disease Biobank. 31203159 2019
CUI: C0238305
Disease: Sickle cell nephropathy
Sickle cell nephropathy
0.010 Biomarker disease BEFREE We identified 91 participants with HbSS or SB0 thalassemia 5-21 years of age enrolled in a longitudinal sickle cell nephropathy cohort study who had a cystatin C measured during early childhood (4-10 years of age). 30592084 2019