|
Herpes encephalitis
|
0.630 |
GeneticVariation
|
disease |
BEFREE |
The narrow disorders impair exclusively (TLR3) or mostly (UNC-93B, TRIF, TRAF3) the TLR3-dependent induction of type I and III IFNs, leading to HSE in apparently otherwise healthy individuals.
|
22347990 |
2011 |
|
Herpes encephalitis
|
0.630 |
SusceptibilityMutation
|
disease |
ORPHANET |
To date, the TRIF-deficient patients with HSE described herein have suffered from no other infections.
|
22105173 |
2011 |
|
Herpes encephalitis
|
0.630 |
GeneticVariation
|
disease |
BEFREE |
Moreover, data revealed mutations in TLR3, TRIF, TBK1 and STAT1 known to be associated with HSE in children but not previously described in adults.
|
26513235 |
2015 |
|
Herpes encephalitis
|
0.630 |
Biomarker
|
disease |
HPO |
|
|
|
|
Herpes encephalitis
|
0.630 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Herpes encephalitis
|
0.630 |
Biomarker
|
disease |
BEFREE |
To date, the TRIF-deficient patients with HSE described herein have suffered from no other infections.
|
22105173 |
2011 |
|
ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 6
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency.
|
22105173 |
2011 |
|
ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 6
|
0.600 |
SusceptibilityMutation
|
disease |
CLINVAR |
|
|
|
|
ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 6
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis.
|
26513235 |
2015 |
|
Herpetic meningoencephalitis
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Herpetic meningoencephalitis
|
0.500 |
SusceptibilityMutation
|
disease |
ORPHANET |
Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency.
|
22105173 |
2011 |
|
Malignant neoplasm of breast
|
0.310 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Malignant neoplasm of breast
|
0.310 |
Biomarker
|
disease |
BEFREE |
We found a significant unique gene expression signature, such as the Toll-like receptor (TLR) 3- and TLR4-induced Toll/interleukin-1 receptor domain-containing adapter molecule 1 (TICAM1)-specific signaling pathway in the breast cancer patients as compared to that of healthy volunteers.
|
30317464 |
2019 |
|
Pneumoconiosis
|
0.310 |
Biomarker
|
disease |
BEFREE |
By applying ICSNPathway analysis to the pneumoconiosis GWAS data, we identified candidate SNPs, genes such as TICAM1 and HIST3H3, and pathways involved in the positive regulation of TNF production that may contribute to pneumoconiosis susceptibility.
|
25445010 |
2015 |
|
Pneumoconiosis
|
0.310 |
Biomarker
|
disease |
CTD_human |
By applying ICSNPathway analysis to the pneumoconiosis GWAS data, we identified candidate SNPs, genes such as TICAM1 and HIST3H3, and pathways involved in the positive regulation of TNF production that may contribute to pneumoconiosis susceptibility.
|
25445010 |
2015 |
|
Herpetic Acute Necrotizing Encephalitis
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Bagassosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Pathway analysis for a genome-wide association study of pneumoconiosis.
|
25445010 |
2015 |
|
Reperfusion Injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways.
|
25780291 |
2015 |
|
Vitiligo
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
|
22561518 |
2012 |
|
Vitiligo
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
|
22561518 |
2012 |
|
Hepatitis C
|
0.090 |
Biomarker
|
disease |
BEFREE |
Correction: Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway.
|
30444918 |
2018 |
|
Hepatitis C
|
0.090 |
Biomarker
|
disease |
BEFREE |
HCV-encoded NS3/4A protease plays an important role in HCV immune evasion by cleaving key adapter proteins VISA and TRIF of the RIG-I-like receptors and Toll-like receptors mediated interferon (IFN) induction pathways.
|
23137809 |
2013 |
|
Hepatitis C
|
0.090 |
Biomarker
|
disease |
BEFREE |
Recent studies established the essential role of TLR3-TICAM-1 pathway in type III IFN production in response to HCV infection.
|
24532585 |
2014 |
|
Hepatitis C
|
0.090 |
Biomarker
|
disease |
BEFREE |
In conclusion, our work revealed a new mechanism for HCV to evade innate immune response by blocking the TLR3-mediated interferon signaling via NS4B-induced TRIF degradation.
|
29782532 |
2018 |
|
Hepatitis C
|
0.090 |
Biomarker
|
disease |
BEFREE |
The activity of asunaprevir-regulated innate immunity signal pathway was assessed with IFN-β promoter or IFN-stimulated responsive element (ISRE) reporter assays and immunoblotting of key signal proteins. siRNA-mediated MAVS and TRIF knockdown of cells was performed to assess the effect of asunaprevir-regulated innate immunity against HCV and DENV.
|
28473813 |
2017 |