Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0276226
Disease: Herpes encephalitis
Herpes encephalitis 		0.630 GeneticVariation disease BEFREE Moreover, data revealed mutations in TLR3, TRIF, TBK1 and STAT1 known to be associated with HSE in children but not previously described in adults. 26513235 2015
CUI: C0276226
Disease: Herpes encephalitis
Herpes encephalitis 		0.630 GeneticVariation disease BEFREE The narrow disorders impair exclusively (TLR3) or mostly (UNC-93B, TRIF, TRAF3) the TLR3-dependent induction of type I and III IFNs, leading to HSE in apparently otherwise healthy individuals. 22347990 2011
CUI: C0276226
Disease: Herpes encephalitis
Herpes encephalitis 		0.630 SusceptibilityMutation disease ORPHANET To date, the TRIF-deficient patients with HSE described herein have suffered from no other infections. 22105173 2011
CUI: C0276226
Disease: Herpes encephalitis
Herpes encephalitis 		0.630 Biomarker disease BEFREE To date, the TRIF-deficient patients with HSE described herein have suffered from no other infections. 22105173 2011
CUI: C0276226
Disease: Herpes encephalitis
Herpes encephalitis 		0.630 Biomarker disease HPO
CUI: C0276226
Disease: Herpes encephalitis
Herpes encephalitis 		0.630 Biomarker disease CTD_human
CUI: C3553869
Disease: ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 6
ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 6 		0.600 Biomarker disease GENOMICS_ENGLAND Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis. 26513235 2015
CUI: C3553869
Disease: ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 6
ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 6 		0.600 GeneticVariation disease UNIPROT Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency. 22105173 2011
CUI: C3553869
Disease: ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 6
ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 6 		0.600 SusceptibilityMutation disease CLINVAR
CUI: C0019385
Disease: Herpetic meningoencephalitis
Herpetic meningoencephalitis 		0.500 SusceptibilityMutation disease ORPHANET Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency. 22105173 2011
CUI: C0019385
Disease: Herpetic meningoencephalitis
Herpetic meningoencephalitis 		0.500 Biomarker disease CTD_human
CUI: C0035235
Disease: Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus Infections 		0.330 Biomarker group BEFREE Neutrophil recruitment and activation are differentially dependent on MyD88/TRIF and MAVS signaling during RSV infection. 31358860 2019
CUI: C0035235
Disease: Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus Infections 		0.330 Biomarker group BEFREE In conclusion, the results of the present study indicate that the TLR4 signaling pathway, in conjunction with MYD88, TRAM, TRIF and the transcription factor AP‑1, may activate immune responses to RSV infection in airway epithelial cells. 24968899 2014
CUI: C0035235
Disease: Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus Infections 		0.330 AlteredExpression group BEFREE We hypothesize that resveratrol inhibits the TRIF-dependent pathway through upregulation of SARM post-RSV infection. 24478430 2014
CUI: C0035235
Disease: Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus Infections 		0.330 Biomarker group CTD_human We hypothesize that resveratrol inhibits the TRIF-dependent pathway through upregulation of SARM post-RSV infection. 24478430 2014
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.310 Biomarker disease BEFREE We found a significant unique gene expression signature, such as the Toll-like receptor (TLR) 3- and TLR4-induced Toll/interleukin-1 receptor domain-containing adapter molecule 1 (TICAM1)-specific signaling pathway in the breast cancer patients as compared to that of healthy volunteers. 30317464 2019
CUI: C0032273
Disease: Pneumoconiosis
Pneumoconiosis 		0.310 Biomarker disease BEFREE By applying ICSNPathway analysis to the pneumoconiosis GWAS data, we identified candidate SNPs, genes such as TICAM1 and HIST3H3, and pathways involved in the positive regulation of TNF production that may contribute to pneumoconiosis susceptibility. 25445010 2015
CUI: C0032273
Disease: Pneumoconiosis
Pneumoconiosis 		0.310 Biomarker disease CTD_human By applying ICSNPathway analysis to the pneumoconiosis GWAS data, we identified candidate SNPs, genes such as TICAM1 and HIST3H3, and pathways involved in the positive regulation of TNF production that may contribute to pneumoconiosis susceptibility. 25445010 2015
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.310 GeneticVariation disease UNIPROT
CUI: C0004681
Disease: Bagassosis
Bagassosis 		0.300 Biomarker disease CTD_human Pathway analysis for a genome-wide association study of pneumoconiosis. 25445010 2015
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.300 Biomarker disease CTD_human Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways. 25780291 2015
CUI: C0001338
Disease: Herpetic Acute Necrotizing Encephalitis
Herpetic Acute Necrotizing Encephalitis 		0.300 Biomarker disease CTD_human
CUI: C0042900
Disease: Vitiligo
Vitiligo 		0.100 GeneticVariation disease GWASCAT Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. 22561518 2012
CUI: C0042900
Disease: Vitiligo
Vitiligo 		0.100 GeneticVariation disease GWASDB Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. 22561518 2012
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.090 Biomarker disease BEFREE Correction: Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway. 30444918 2018