CTBP1, C-terminal binding protein 1, 1487

N. diseases: 154; N. variants: 4
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.040 AlteredExpression disease BEFREE Our findings suggest an important role of CtBP1 in the transcriptional control of p16INK4a and Brca1, with CtBP1 overexpression potentially contributing to increased proliferation and DNA damage in melanoma. 23303449 2013
CUI: C0025202
Disease: melanoma
melanoma 		0.040 AlteredExpression disease BEFREE Expression of miR-137 in melanoma cell lines was found to inversely correlate with CtBP1 levels. 21278922 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.040 AlteredExpression disease LHGDN To understand the effect of CtBP1 we identified putative LEF/TCF target genes found to be strongly expressed in melanoma using DNA microarray analysis. 19216735 2009
CUI: C0025202
Disease: melanoma
melanoma 		0.040 Biomarker disease BEFREE The present study was performed to evaluate a more general role of CtBP1 in human melanoma and identify further CtBP1-regulated target genes. 19216735 2009
CUI: C0025202
Disease: melanoma
melanoma 		0.040 AlteredExpression disease BEFREE Furthermore, we observed strong expression of CtBP1 in primary melanocytes but a loss of wild-type CtBP1 expression in malignant melanoma in vitro and in vivo. 12384563 2002