CTBP2, C-terminal binding protein 2, 1488

N. diseases: 62; N. variants: 13
Disease: polyps ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0032584
Disease: polyps
polyps 		0.010 Biomarker phenotype BEFREE Ctbp2 heterozygosity increased the median survival of Apc<sup>min/+</sup> mice from 21 to 48 weeks, and reduced polyp formation by 90%, with Ctbp2<sup>+/-</sup> polyps exhibiting reduced levels of β-catenin and its oncogenic transcriptional target, cyclin D1. 28414304 2017