|
Scleroderma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We demonstrated that Repsox has the most potent inhibitory effects on TGF-β-induced expression of CTGF and collagen of cultured normal dermal fibroblasts in vitro and their constitutive overexpression of scleroderma fibroblast in vitro.
|
28418584 |
2017 |
|
Scleroderma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We further found that the expression of TGF-β1, CTGF and type I and type III collagen mRNA was inhibited by MK886 in scleroderma fibroblasts.
|
21352343 |
2011 |
|
Scleroderma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We assessed the possible association between 7 single-nucleotide polymorphisms (SNP) in the CTGF gene and scleroderma in a French population (registration number 2006/0182).
|
20032097 |
2010 |
|
Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Scleroderma lung fibroblasts and normal lung fibroblasts treated with CTGF demonstrated increased rate of migration in a wound healing assay.
|
18676875 |
2008 |
|
Scleroderma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
This element was shown previously to mediate up-regulation of the CCN2 promoter in SSc fibroblasts.
|
17317656 |
2007 |
|
Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, HGF suppressed collagen synthesis and mRNA levels of procollagenalpha1(I) and connective tissue growth factor (CTGF) in SSc fibroblasts.
|
17164998 |
2006 |
|
Scleroderma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hypoxia induces expression of connective tissue growth factor in scleroderma skin fibroblasts.
|
17034590 |
2006 |
|
Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review discusses recent information regarding insights into connective tissue growth factor biology and, using scleroderma as a model system, the part connective tissue growth factor might play in fibrotic disease.
|
14962082 |
2004 |
|
Scleroderma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Constitutive connective tissue growth factor expression in scleroderma fibroblasts is dependent on Sp1.
|
12888575 |
2003 |
|
Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These include the role of transforming growth factor-beta (TGF-beta) and connective tissue growth factor (CTGF) and their receptors in the fibrotic process in scleroderma and the overview of the transcription factors involved in regulation of the human alpha2 (I) collagen (COL1A2) gene.
|
11861221 |
2002 |
|
Scleroderma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, mutation of the previously termed TGFbetaRE reduces ccn2 (ctgf) promoter activity in scleroderma fibroblasts to that seen in normal fibroblasts.
|
11376132 |
2001 |
|
Scleroderma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
By sampling dermal interstitial fluid using a suction blister device, we show that CTGF levels are greatly elevated in the dermis of scleroderma patients compared with healthy controls and that Iloprost infusion causes a marked decrease in dermal CTGF levels.
|
11457877 |
2001 |
|
Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transforming growth factor-beta and connective tissue growth factor: key cytokines in scleroderma pathogenesis.
|
11698729 |
2001 |
|
Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although TNFalpha was able to repress TGF-beta-induced CTGF and collagen synthesis both in normal and scleroderma skin fibroblasts, fibroblasts cultured from scleroderma patients were more resistant to TNFalpha as TNFalpha was unable to suppress the basal level of CTGF expression in scleroderma fibroblasts.
|
10809757 |
2000 |
|
Scleroderma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
One such gene consistently up-regulated in scleroderma cells coded for human connective tissue growth factor (CTGF).
|
10942593 |
2000 |
|
Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Connective tissue growth factor (CTGF) is a member of an emerging CCN gene family that is implicated in various diseases associated with fibro-proliferative disorder including scleroderma and atherosclerosis.
|
10601320 |
1999 |
|
Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Connective tissue growth factor (CTGF), a cytokine of the family of growth regulators comprising sef10, cyr61, CTGF and nov, has recently been described in association with scleroderma and other scarring conditions.
|
9551391 |
1998 |