|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Liraglutide can improve renal alterations associated with diabetes as it reduced CTGF expression and increased BMP-7 expression.
|
31127659 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In terms of CCN2 regulation by a diabetes metabolic environment and related mechanisms, the author's laboratory and others have progressively shown that advanced glycation-end products, protein kinase C isoforms, saturated fatty acids, reactive oxygen species and haemodynamic factors upregulate CCN2 in relevant cell and animal systems.
|
29411334 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Despite the biological role of CTGF in diabetes, it still remains unclear how CTGF expression is regulated.
|
30400798 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry of human liver tissues validated the correlations between CTGF expression and diabetes or obesity as well as activation of liver macrophages in patients with non-viral HCC.
|
26739296 |
2016 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Intravitreal injection of ranibizumab and CTGF shRNA improves retinal gene expression and microvessel ultrastructure in a rodent model of diabetes.
|
24451141 |
2014 |
|
Diabetes
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
However, the CTGF methylation levels in the two diabetes groups were significantly lower than those in the NDM group (P<0.05), with the lowest methylation level in the DN group (P<0.05).
|
24676352 |
2014 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, RT-FQ-PCR and western blot analyses showed that TGF-β1, Smad2, CTGF and FN protein and mRNA expression was significantly increased in the diabetes untreated model group compared with the normal control group.
|
24595557 |
2014 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Protective effect of statin therapy on connective tissue growth factor induction by diabetes in vivo and high glucose in vitro.
|
24192280 |
2013 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Specifically, the association between CTGF polymorphism and non-invasive markers of beta-cell area derived from oral glucose tolerance test was studied in subjects without diabetes.
|
22045431 |
2011 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Importantly, induction of diabetes in CTGF-transgenic mice resulted in a further elevation of endogenous CTGF mRNA expression and protein in the glomerular mesangium.
|
18075496 |
2008 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied the relationship between CTGF and renal pathology in streptozotocin (STZ)-induced diabetes in C57BL/6J mice.
|
16380465 |
2006 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine.
|
12446618 |
2002 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Connective tissue growth factor (CTGF), also known as insulin-like growth factor-binding protein-related protein-2 (IGFBP-rP2), is a potent inducer of extracellular matrix synthesis and angiogenesis and is increased in tissues from rodent models of diabetes.
|
11316739 |
2001 |