|
Renal fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our previous study demonstrated that fibroblast growth factor 21 (FGF21) prevented DN associated with the suppressing renal connective tissue growth factor expression, a key marker of renal fibrosis.
|
31701691 |
2020 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Connective tissue growth factor (CTGF) is a cytokine upregulated in RTECs during renal fibrosis.
|
31637729 |
2020 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This section briefly describes the role and molecular mechanisms of CTGF in renal fibrosis and also discusses the potential value of targeting CCN2 for the treatment of renal fibrosis.
|
31399974 |
2019 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
During hypoxia, p53 upregulation induced by HIF-1α suppresses cell cycle progression, leading to the accumulation of G2/M cells, and activates profibrotic TGF-β and CTGF-mediated signaling pathways, causing extracellular matrix production and renal fibrosis.
|
30032308 |
2019 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vitro studies have demonstrated that CCN2 regulates the production of extracellular matrix (ECM) proteins and epithelial-mesenchymal transition (EMT), and could therefore contribute to renal fibrosis.
|
29160908 |
2018 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
CCN2 has been shown to be closely involved in the progression of renal fibrosis, indicating the potential of CCN2 inhibition as a therapeutic target.
|
27734390 |
2017 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein, we describe unilateral ureteral obstruction in mice as an animal model of renal fibrosis and methods for immunohistochemical analyses of extracellular matrix proteins and CCN2.
|
27734395 |
2017 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Connective tissue growth factor has pleiotropic effects in the setting of renal fibrosis; this study adds a potentially new mechanism for the profibrotic effects of connective tissue growth factor.
|
28938948 |
2017 |
|
Renal fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study was to determine whether miR-30c was involved in the mechanism of renal fibrosis by inhibiting target CTGF expression in DN.
|
26775556 |
2016 |
|
Renal fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study was designed to detect whether the delivery of CTGF siRNA in vivo directly ameliorates renal fibrosis.
|
26257513 |
2015 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review reports the evidence for its expression in human and animal models of chronic kidney disease and summarizes data showing that anti-CTGF therapy can successfully attenuate fibrotic changes in several such models, suggesting that therapies targeting CTGF and events downstream of it in renal cells may be useful for the treatment of human kidney fibrosis.
|
23110747 |
2013 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also discuss the therapeutic potential of targeting CCN2 for the treatment of renal fibrosis.
|
19955828 |
2010 |
|
Renal fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Enhanced and prolonged expression of connective tissue growth factor (CTGF) is associated with kidney fibrosis.
|
22166649 |
2010 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Connective tissue growth factor (CTGF) plays a key role in renal fibrosis.
|
20237235 |
2010 |
|
Renal fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Because sphingosine kinase-1 (SK-1) activity is also upregulated by TGF-beta, we studied its effect on CTGF expression and on the development of renal fibrosis.
|
19657322 |
2009 |
|
Renal fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase activation and renal fibrosis.
|
18401334 |
2008 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This suggests CTGF could be a potential target for kidney fibrosis.
|
17300978 |
2008 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Integrated actions of transforming growth factor-beta1 and connective tissue growth factor in renal fibrosis.
|
15536170 |
2005 |
|
Renal fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
CTGF induction of TN-C, a marker of epithelial-mesenchymal transdifferentiation (EMT), with no significant induction of collagenous protein synthesis in HTECs, may suggest a more predominant role for CTGF in EMT rather than induction of excessive collagen deposition by HTECs during renal fibrosis.
|
12217862 |
2002 |
|
Renal fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of connective tissue growth factor in human renal fibrosis.
|
9551391 |
1998 |