|
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
BEFREE |
This study examined the association of IL23R and IL17A gene SNPs with ulcerative colitis susceptibility in a population in China.
|
22984500 |
2012 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The study indicates that IL23R-rs11805303 and PTPN2-rs2542151 might contribute to the development of UC and NOD2-P268S might be involved in the etiology of CD in the Chinese Han population.
|
22426692 |
2012 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
IL-23R gene variants have been identified as risk factors for two major inflammatory bowel diseases (IBDs), Crohn's disease and ulcerative colitis, but how they contribute to disease is poorly understood.
|
22262659 |
2012 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-23 is involved in pro-inflammatory signaling; genetic variation in the interleukin-23 receptor (IL23R) has been consistently associated with CD and UC risk.
|
22154103 |
2012 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In addition to the IL2/IL21 locus, we observed association of the TT genotype of SNP rs1545620 in MYO9B with UC (P = 0.0169; OR = 0.29, 95% CI 0.11-0.78) and association of rs17375018 in IL23R with pancolitis in Chinese UC patients (P = 0.002; OR = 2.38, 95% CI 1.41-4.02).
|
21648020 |
2011 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies (GWAS) in several populations have demonstrated significant association of the IL23R gene with IBD (Crohn's disease (CD) and ulcerative colitis (UC)) and psoriasis, suggesting that perturbation of the IL-23 signaling pathway is relevant to the pathophysiology of these diseases.
|
22022372 |
2011 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
|
21297633 |
2011 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that neither TNFSF15 nor IL23R variants contribute to UC susceptibility in Koreans.
|
21228792 |
2011 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
|
21297633 |
2011 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), rs2066845" genes_norm="64127">Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - rs11209026;rs901312933" genes_norm="149233;55054">Arg381Gln (rs11209026) and ATG16L1 - rs2241880;s2241880;rs1384936174" genes_norm="55054;64127">Thr300Ala (rs2241880).
|
20082483 |
2010 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
|
20228799 |
2010 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
|
20228799 |
2010 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genotyping for UC-associated variants in the IL23R gene and in the IL2/IL21 region was performed.
|
20197757 |
2010 |
|
Ulcerative Colitis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
IL23R was expressed in both CD and UC with a great variability.
|
20192940 |
2010 |
|
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
CTD_human |
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
|
20228799 |
2010 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that IL23R R381Q confers protection against CD and that L310P confers protection against UC in females.
|
19294505 |
2010 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease.
|
19455118 |
2009 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We confirm the association of CD with variants in the IL-23R and ATG16L1 genes and the more modest association of the IL-23R R381Q variant with UC.
|
19276991 |
2009 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
|
19122664 |
2009 |
|
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our study is the first to demonstrate association of IL23R with CD and UC in Swedish patients with IBD.
|
19175939 |
2009 |
|
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
CTD_human |
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
|
19122664 |
2009 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Our study is the first to demonstrate association of IL23R with CD and UC in Swedish patients with IBD.
|
19175939 |
2009 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
|
19122664 |
2009 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
|
19122664 |
2009 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
|
19915572 |
2009 |