Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
AS patients with PA showed an earlier age of disease onset (p=0.021), longer disease duration (p=0.020) and longer duration of AS symptoms from onset (p=0.034) than AS patients without PA. We found significant associations with the presence of PA at disease onset in 14 SNPs located in 10 genes: HLA-DQB2 (rs2857210 and rs9276615), HLA-DOB (rs2857151, rs2621332 and rs1383261), JAK2 (rs7857730), IL-23R (rs11209008 and rs10489630), CYP1B1 (rs1056836), NELL1 (rs8176786), KL (rs564481), and MEFV (rs224204), IL-2RB (rs743777) and IL-1A (rs1800587).
|
30299251 |
2019 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-23 receptor polymorphism (rs10889677 A/C) in ankylosing spondylitis: Meta-analysis in Caucasian and Asian populations.
|
29198991 |
2018 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The association between IL-23R polymorphisms and AS was evaluated by odds ratio (OR) and 95% confidence intervals (95% CI).
|
29944013 |
2018 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We replicated associations between AS and the polymorphisms in TNF (rs1800629), TNFRSF1A (rs4149570), and IL23R (rs11209026).
|
30208882 |
2018 |
Ankylosing spondylitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The results suggested that the genetic susceptibility for AS is associated with the nine SNPs of IL-23R in overall population.
|
30322951 |
2018 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We first detected that rs6693831 and rs1884444 in IL-23R gene and rs2275913 in IL-17A gene have genetic association with AS.
|
29050281 |
2017 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Through mounting genetic investigations, it has been established that IL12B and IL23R gene single nucleotide polymorphisms have significant associations with autoimmune diseases including inflammatory bowel disease, psoriasis, and ankylosing spondylitis.
|
28276258 |
2017 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We used publicly available epigenomic information and historical genetic association data to identify a putative regulatory element (PRE) in the intergenic region between IL23R and IL12RB2, which includes two single-nucleotide polymorphisms (SNPs) independently associated with AS-rs924080 (P=2 × 10<sup>-3</sup>) and rs11578380 (P=2 × 10<sup>-4</sup>).
|
28381868 |
2017 |
Ankylosing spondylitis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
IL23R and IL12RB2 mRNA levels in CD4+ T cells were compared between cases homozygous for the AS-risk 'A' allele and the protective 'G' allele.
|
26916345 |
2016 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recent studies have suggested the association of IL-23R polymorphisms with bone and articular inflammation in diseases such as ankylosing spondylitis and rheumatoid arthritis.
|
26016922 |
2016 |
Ankylosing spondylitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Their gut origin, effector phenotype and expression of multiple AS-associated genes, such as IL7R and IL23R, makes them potential contributors to the pathogenesis of AS.
|
27165176 |
2016 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In contrast, IL-23R gene polymorphisms may serve a protective role in AS and IBD.
|
27458846 |
2016 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The subunit of IL-23 (IL12B) and its receptor (IL23R) gene single-nucleotide polymorphisms (SNPs) have been shown to be associated with several autoimmune diseases such as inflammatory bowel disease, psoriasis and ankylosing spondylitis.
|
24547735 |
2014 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Besides TNF, the IL-23/IL-17 axis is emerging as an important inflammatory pathway in SpA, as a SNP in the IL-23R locus has been associated with developing AS, mice overexpressing IL-23 develop SpA-like features and IL-17 blockade has been shown to be efficacious for AS patients in a phase II trial.
|
23969080 |
2014 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this study, we evaluated five important single nucleotide polymorphisms (SNPs) of the IL-23R gene which confers susceptibility to AS, and its effects on the severity of the disease in HLA-B27 positive and negative patients and several subtypes of HLA-B27.
|
24998354 |
2014 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci.
|
23749187 |
2013 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Marked diversity of IL23R gene haplotype variants in rheumatoid arthritis comparing with Crohn's disease and ankylosing spondylitis.
|
23054009 |
2013 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A 170-kb region containing IL23R and its flanking regions was sequenced in 50 patients with AS and 50 ethnically matched healthy control subjects from a Han Chinese population.
|
23606107 |
2013 |
Ankylosing spondylitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
We found no evidence for an association between the other two SNPs of IL-23R and AS.
|
23840727 |
2013 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The nonsynonymous single-nucleotide polymorphism (SNP) rs11209026 (Arg381Gln) in the IL23R gene has reproducibly been shown to be associated with ankylosing spondylitis (AS).
|
23818276 |
2013 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Two single nucleotide polymorphisms (SNPs), rs1004819 and rs10889677, of the interleukin-23 receptor (IL-23R) gene have been shown to be associated with AS susceptibility in European populations.
|
23767933 |
2013 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-23 receptor genetic polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis.
|
21253733 |
2012 |
Ankylosing spondylitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis shows that the IL-23R polymorphisms are associated with the development of AS in Europeans.
|
22089529 |
2012 |