|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Casein kinase (CK) 2 activation has been implicated in the proliferation of various tumor types and resistance to chemotherapy.
|
31098863 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Exogenous expression of CK2 enhanced cell growth and tumor growth in mice, while depletion or inhibition of CK2 expression decreased MB tumorigenesis.
|
31406250 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PTEN, a tumor suppressor protein, gets deactivated by casein kinase 2 (CK2) and glycogen synthase kinase 3β (GSK3β), which are the major causes of PI3K/AKT-driven tumors.
|
27960601 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest a potential role of CK2 inhibitors in combination therapies against cancer.<b>Significance:</b> These findings demonstrate the modulatory effects of casein kinase 2 inhibitors on myeloid cell differentiation in the tumor microenvironment, which subsequently synergize with the antitumor effects of checkpoint inhibitor CTLA4.<i></i>.
|
30139814 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Casein kinase 2 (CK2) and glycogen synthase kinase-3beta (GSK3β) are responsible for the phosphorylation of a tumor suppressor protein (PTEN) in a cooperative manner which causes its deactivation.
|
30288222 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
While mutations identified in the <i>DDX3X</i> genes of human medulloblastoma patients can enhance CK1 activity in living cells, the mechanism of CK1 activation by DDX3X points to a possible therapeutic approach in CK1-related diseases such as those caused by tumors driven by aberrant Wnt/β-catenin and Sonic hedgehog (SHH) activation.
|
29222110 |
2018 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
On the other hand, CK2 is abnormally elevated in a variety of tumors, and is considered as a promising therapeutic target.
|
28748912 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
New research suggests that altering a subset of extracellular matrix factors, including interferon regulatory factor (IRF)3 and casein kinase (CK)2, may decrease the migratory potential of these aggressive tumors.
|
28774478 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We furthermore found gender-specific differences within these subgroups, revealing most significant increase in overall survival rates in male patients with tumors in right colon expressing low levels of CK1δ RNA.
|
26738869 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Casein kinase II contributes to the growth and survival of malignant gliomas and attracts increasing attention as a therapeutic target in these tumors.
|
27098015 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TBG nanocapsules delivered siRNAs targeting CDK11 or CK2 in mice carrying TNBC xenograft tumors.
|
25837326 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CK2 has enhanced expression or activity in numerous cancers, including GBM, and it has been demonstrated that inhibitors of CK2 regressed tumor growth in GBM xenograft mouse models.
|
25241897 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.
|
26219304 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The casein kinase 1A1 gene (CSNK1A1) is a putative tumor suppressor gene located in the common deleted region for del(5q) myelodysplastic syndrome (MDS).
|
25242043 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We identified casein kinase 1α (CK1α) as a direct target of miR-155 control which enhanced β-catenin signaling and cyclin D1 expression, promoting tumor cell growth.
|
22350414 |
2012 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
PML mutants that are resistant to CK2 phosphorylation display increased tumor suppressive functions in assays measuring apoptosis, replicative senescence, and in xenograft models.
|
18566754 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The protein kinase casein kinase II (CK2) is a ubiquitously expressed serine-threonine kinase and its activity is enhanced in all human tumors examined so far.
|
17671722 |
2007 |