|
melanoma
|
0.500 |
Biomarker
|
disease |
LHGDN |
Mutational analysis of CTNNB1 identified somatic mutations in 1 primary melanoma and 1 melanoma metastasis from 2 different patients (5%).
|
12124804 |
2002 |
|
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
A significant fraction of primary human melanomas exhibit deregulation (via aberrant nuclear accumulation) of beta-catenin, leading us to examine its role in melanoma growth and survival.
|
12235125 |
2002 |
|
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results indicate that Wnt/β-catenin pathways in human melanoma may be involved in immunosuppression and immunoresistance in both induction and effector phases of antitumor immunoresponses partly through IL-10 production, and they may be attractive targets for restoring immunocompetence in patients with Wnt/β-catenin-activated melanoma.
|
22815287 |
2012 |
|
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
To determine whether this difference in mutation frequency reflected an in vitro culturing artefact, exon 3 of CTNNB1 was screened in a panel of 62 melanoma cell lines.
|
11930117 |
2002 |
|
melanoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We show that β-catenin mRNA levels are negatively correlated with miR-214 in melanoma.
|
31338875 |
2019 |
|
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
In summary, we conclude that loss of E-cadherin and cytoplasmatic beta-catenin induces p38-mediated NFkappaB activation, potentially revealing an important mechanism of tumorigenesis in malignant melanomas.
|
15378016 |
2004 |
|
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Previous studies have revealed that β‑catenin is associated with TRAIL resistance in melanoma and colorectal tumors.
|
30132512 |
2018 |
|
melanoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The results indicate that induction of Nr-CAM transcription by beta-catenin or plakoglobin plays a role in melanoma and colon cancer tumorigenesis, probably by promoting cell growth and motility.
|
12183361 |
2002 |
|
melanoma
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
Mutational analysis of CTNNB1 identified somatic mutations in 1 primary melanoma and 1 melanoma metastasis from 2 different patients (5%).
|
12124804 |
2002 |
|
melanoma
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
One out of 62 (1.6%) cell lines was found to carry a mutation, indicating that aberration of the Wnt-1/wingless pathway through activation of beta-catenin is a rare event, even in melanoma cell lines.
|
11930117 |
2002 |
|
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry revealed a significant loss of membranous beta-catenin staining between the primary and metastatic melanomas as well as between radial and vertical growth phase.
|
11950921 |
2002 |
|
melanoma
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma.
|
11351304 |
2001 |
|
melanoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Several transcription factors and signaling pathways involved in the regulation of MITF expression and/or activity such as the Wnt/β-catenin pathway are broadly utilized by various types of tumors, whereas others, e.g., BRAF(V600E)/ERK1/2 are more specific for melanoma.
|
25433395 |
2015 |
|
melanoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The activation of oncogenic Wnt/β-catenin pathway in melanoma contributes to a lack of T-cell infiltration.
|
28412591 |
2017 |
|
melanoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
beta-catenin mutations have been found not only in melanoma and prostatic carcinoma but also in hepatocellular carcinomas in human, c-myc, H-ras genes transgenic mice and chemically-induced models.
|
10811985 |
2000 |
|
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study demonstrates that REGγ is a central molecule in the development of melanoma by regulating Wnt/β-catenin pathway.
|
28605165 |
2017 |
|
melanoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Thus, Wnt/β-catenin signaling and AXIN1 may regulate the efficacy of inhibitors of BRAF(V600E), suggesting that manipulation of the Wnt/β-catenin pathway could be combined with BRAF inhibitors to treat melanoma.
|
22234612 |
2012 |
|
melanoma
|
0.500 |
AlteredExpression
|
disease |
LHGDN |
Our results may explain the observed loss of nuclear beta-catenin with melanoma progression in human tumors, which could reflect a dysregulation of cellular differentiation through a loss of homeostatic Wnt/beta-catenin signaling.
|
19144919 |
2009 |
|
melanoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, melanoma cells expressing relative low level of β-catenin and an invasive markers signature were associated to the TNF-α-induced pro-inflammatory pathway and to the chemotherapy resistance, suggesting that the co-existence of melanoma subpopulations with distinct biological properties could influence the impact of chemo- and immunotherapy.
|
27175588 |
2016 |
|
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Unexpectedly, β-catenin acts mainly independent of the TCF/LEF dependent canonical Wnt-signaling pathway in resistance development, which partly explains previous contradictory results about the role of β-catenin in melanoma progression and therapy resistance.
|
27428425 |
2016 |
|
melanoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Congruently, the transcriptional activity of β-catenin regulating expression of β-catenin target genes was not observed in several melanoma cell lines.
|
21584489 |
2011 |
|
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Collectively, our findings support the notion that targeting the oncogenic β-catenin by lycorine is a new option to inhibit melanoma cell metastasis, providing a good drug candidate potential for development novel therapeutics against metastatic melanoma.
|
30565685 |
2019 |
|
melanoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Our data indicate that during melanoma progression an increased dependency on the transcriptional function of beta-catenin takes place.
|
21858114 |
2011 |
|
melanoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings demonstrate that beta-catenin mutations are rare in primary melanoma, in contrast to the situation in melanoma cell lines.
|
10027390 |
1999 |
|
melanoma
|
0.500 |
AlteredExpression
|
disease |
LHGDN |
Concomitantly, an increase in the nuclear level of beta-catenin occurred in melanoma cells, together with a sixfold increase in beta-catenin-dependent transcription.
|
15987741 |
2005 |